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    VAV2 vav guanine nucleotide exchange factor 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 713227, updated on 17-Aug-2024

    Summary

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    Official Symbol
    VAV2provided by VGNC
    Official Full Name
    vav guanine nucleotide exchange factor 2provided by VGNC
    Primary source
    VGNC:VGNC:78758
    See related
    Ensembl:ENSMMUG00000017214
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See VAV2 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 15 NC_041768.1 (4250763..4486378)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 15 NC_027907.1 (4360814..4597693)

    Chromosome 15 - NC_041768.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114672698 Neighboring gene BRD3 opposite strand Neighboring gene 60S ribosomal protein L10-like Neighboring gene sarcosine dehydrogenase Neighboring gene uncharacterized LOC114672699 Neighboring gene dopamine beta-hydroxylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanine nucleotide exchange factor VAV2
    Names
    vav 2 guanine nucleotide exchange factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001265633.1 → NP_001252562.1  guanine nucleotide exchange factor VAV2

      See identical proteins and their annotated locations for NP_001252562.1

      Status: PROVISIONAL

      Source sequence(s)
      JV565178
      UniProtKB/TrEMBL
      A0A5F7ZSN7, F7HEA0, I2CU78
      Related
      ENSMMUP00000022644.4, ENSMMUT00000024200.4
      Conserved Domains (8) summary
      cd10406
      Location:667 → 769
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:819 → 876
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:590 → 649
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      cd00029
      Location:524 → 571
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:389 → 516
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00169
      Location:406 → 512
      PH; PH domain
      pfam00621
      Location:202 → 375
      RhoGEF; RhoGEF domain
      pfam11971
      Location:18 → 103
      CAMSAP_CH; CAMSAP CH domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041768.1 Reference Mmul_10 Primary Assembly

      Range
      4250763..4486378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015116410.2 → XP_014971896.1  guanine nucleotide exchange factor VAV2 isoform X1

      UniProtKB/TrEMBL
      A0A1D5QH15
      Conserved Domains (7) summary
      cd10406
      Location:685 → 787
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:837 → 894
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:608 → 667
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      smart00325
      Location:202 → 375
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01223
      Location:389 → 534
      PH_Vav; Vav pleckstrin homology (PH) domain
      cd21263
      Location:2 → 120
      CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
      cd20868
      Location:537 → 594
      C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

    2. XM_015116414.2 → XP_014971900.1  guanine nucleotide exchange factor VAV2 isoform X5

      UniProtKB/TrEMBL
      A0A1D5QH15
      Related
      ENSMMUP00000047335.2, ENSMMUT00000065546.2
      Conserved Domains (7) summary
      cd10406
      Location:685 → 787
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:808 → 865
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:608 → 667
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      smart00325
      Location:202 → 375
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01223
      Location:389 → 534
      PH_Vav; Vav pleckstrin homology (PH) domain
      cd21263
      Location:2 → 120
      CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
      cd20868
      Location:537 → 594
      C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

    3. XM_015116411.2 → XP_014971897.1  guanine nucleotide exchange factor VAV2 isoform X2

      UniProtKB/TrEMBL
      A0A1D5QH15
      Related
      ENSMMUP00000042098.2, ENSMMUT00000076235.2
      Conserved Domains (7) summary
      cd10406
      Location:680 → 782
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:832 → 889
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:603 → 662
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      smart00325
      Location:197 → 370
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01223
      Location:384 → 529
      PH_Vav; Vav pleckstrin homology (PH) domain
      cd21263
      Location:2 → 120
      CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
      cd20868
      Location:532 → 589
      C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

    4. XM_015116412.2 → XP_014971898.1  guanine nucleotide exchange factor VAV2 isoform X3

      UniProtKB/TrEMBL
      A0A1D5Q9M3, A0A5F7ZSN7
      Related
      ENSMMUP00000044741.2, ENSMMUT00000077520.2
      Conserved Domains (8) summary
      cd10406
      Location:662 → 764
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:814 → 871
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:585 → 644
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      cd00029
      Location:519 → 566
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:389 → 511
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00169
      Location:406 → 507
      PH; PH domain
      pfam00621
      Location:202 → 375
      RhoGEF; RhoGEF domain
      pfam11971
      Location:18 → 103
      CAMSAP_CH; CAMSAP CH domain

    5. XM_015116413.2 → XP_014971899.1  guanine nucleotide exchange factor VAV2 isoform X4

      UniProtKB/TrEMBL
      A0A5F7ZSN7
      Related
      ENSMMUP00000067653.1, ENSMMUT00000087343.1
      Conserved Domains (8) summary
      cd10406
      Location:657 → 759
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:809 → 866
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:580 → 639
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      cd00029
      Location:514 → 561
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:384 → 506
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00169
      Location:401 → 502
      PH; PH domain
      pfam00621
      Location:197 → 370
      RhoGEF; RhoGEF domain
      pfam11971
      Location:18 → 103
      CAMSAP_CH; CAMSAP CH domain

    6. XM_015116415.2 → XP_014971901.1  guanine nucleotide exchange factor VAV2 isoform X6

      UniProtKB/TrEMBL
      A0A1D5QH15
      Related
      ENSMMUP00000080823.1, ENSMMUT00000097146.1
      Conserved Domains (8) summary
      cd10406
      Location:657 → 759
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:780 → 837
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:580 → 639
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      cd00029
      Location:514 → 561
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:384 → 506
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00169
      Location:401 → 502
      PH; PH domain
      pfam00621
      Location:197 → 370
      RhoGEF; RhoGEF domain
      pfam11971
      Location:18 → 103
      CAMSAP_CH; CAMSAP CH domain
    Nucleotide Protein
    Heading Accession and Version

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