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    CXCR4 C-X-C motif chemokine receptor 4 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 707329, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CXCR4provided by VGNC
    Official Full Name
    C-X-C motif chemokine receptor 4provided by VGNC
    Primary source
    VGNC:VGNC:71572
    See related
    Ensembl:ENSMMUG00000011918
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See CXCR4 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 12 NC_041765.1 (21291083..21294316, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 12 NC_027904.1 (21637417..21640662, complement)

    Chromosome 12 - NC_041765.1Genomic Context describing neighboring genes Neighboring gene glycoprotein endo-alpha-1,2-mannosidase-like protein pseudogene Neighboring gene aspartyl-tRNA synthetase 1 Neighboring gene uncharacterized LOC114671318 Neighboring gene uncharacterized LOC106992562 Neighboring gene heterogeneous nuclear ribonucleoprotein K pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New widespread CXCR4 allele in rhesus macaques does not predict subspecies or clinical evolution. Prétet JL, et al. AIDS Res Hum Retroviruses, 1998 May 1. PMID 9591719
    2. Different mutational pathways to CXCR4 coreceptor switch of CCR5-using simian-human immunodeficiency virus. Ho SH, et al. J Virol, 2008 Jun. PMID 18385246, Free PMC Article
    3. Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entry. Chen Z, et al. J Virol, 1997 Apr. PMID 9060623, Free PMC Article
    4. Glucocorticoid-induced eosinopenia results from CXCR4-dependent bone marrow migration. Hong SG, et al. Blood, 2020 Dec 3. PMID 32659786, Free PMC Article
    5. CXCR7/CXCR4/CXCL12 axis regulates the proliferation, migration, survival and tube formation of choroid-retinal endothelial cells. Jin J, et al. Ophthalmic Res, 2013. PMID 23549077

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glucocorticoid-induced eosinopenia results from CXCR4-dependent bone marrow migration.
      Title: Glucocorticoid-induced eosinopenia results from CXCR4-dependent bone marrow migration.
    2. The increased CXCR4 and CXCR7 expression resulted in increased SDF-1-induced RF/6A cell migration and tube formation.
      Title: TGF-β1 enhances SDF-1-induced migration and tube formation of choroid-retinal endothelial cells by up-regulating CXCR4 and CXCR7 expression.
    3. The CXCR7/CXCR4/CXCL12 axis plays an important role in the formation of CNV, and may become a novel target for the treatment of choroidal neovascularization-associated diseases.
      Title: CXCR7/CXCR4/CXCL12 axis regulates the proliferation, migration, survival and tube formation of choroid-retinal endothelial cells.
    4. These findings suggest that FBLN5 may interfere with choroidal neovascularization by downregulating VEGF, CXCR4, and TGFB1 expression and inhibiting choroidl endothelial cell proliferation.
      Title: Overexpression of fibulin-5 in retinal pigment epithelial cells inhibits cell proliferation and migration and downregulates VEGF, CXCR4, and TGFB1 expression in cocultured choroidal endothelial cells.
    5. Virus recovered from CA28 plasma (SHIV(CA28NP)) used both CCR5 and CXCR4 for entry, but the virus recovered from lymph node (SHIV(CA28NL)) used CXCR4 almost exclusively
      Title: Different mutational pathways to CXCR4 coreceptor switch of CCR5-using simian-human immunodeficiency virus.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables chemokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cytokine binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in brain development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neurogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C-X-C chemokine receptor type 4
    Names
    CXC-R4
    CXCR-4
    LESTR
    SDF-1 receptor
    chemokine (C-X-C motif) receptor 4
    fusin
    leukocyte-derived seven transmembrane domain receptor
    stromal cell-derived factor 1 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042645.1 → NP_001036110.1  C-X-C chemokine receptor type 4

      See identical proteins and their annotated locations for NP_001036110.1

      Status: PROVISIONAL

      Source sequence(s)
      AF001928
      UniProtKB/Swiss-Prot
      O02745, O46428, P79394
      UniProtKB/TrEMBL
      A0A1D5QA04, H9ZDD5
      Related
      ENSMMUP00000044872.2, ENSMMUT00000078825.2
      Conserved Domains (2) summary
      cd15179
      Location:39 → 313
      7tmA_CXCR4; CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors
      pfam12109
      Location:6 → 38
      CXCR4_N; CXCR4 Chemokine receptor N terminal

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041765.1 Reference Mmul_10 Primary Assembly

      Range
      21291083..21294316 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P79394.1 GenPept UniProtKB/Swiss-Prot:P79394

    Gene LinkOut

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