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    PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 701974, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PIK3C2Bprovided by VGNC
    Official Full Name
    phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 betaprovided by VGNC
    Primary source
    VGNC:VGNC:100035
    See related
    Ensembl:ENSMMUG00000016563
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PIK3C2B in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (61930806..62001939, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (162102830..162174051)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S12 pseudogene Neighboring gene protein phosphatase 1 regulatory subunit 15B Neighboring gene uncharacterized LOC106994037 Neighboring gene transfer RNA lysine (anticodon UUU) Neighboring gene transfer RNA lysine (anticodon UUU)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
    Names
    phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta
    phosphoinositide-3-kinase, class 2, beta polypeptide
    XP_014975002.1
    XP_014975006.1
    XP_014975013.1
    XP_014975021.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      61930806..62001939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015119520.2 → XP_014975006.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X2

      UniProtKB/TrEMBL
      G7MEU7
      Conserved Domains (7) summary
      cd00895
      Location:978 → 1331
      PI3Kc_C2_beta; Catalytic domain of Class II Phosphoinositide 3-kinase beta
      cd07290
      Location:1360 → 1468
      PX_PI3K_C2_beta; The phosphoinositide binding Phox Homology Domain of the Beta Isoform of Class II Phosphoinositide 3-Kinases
      cd04012
      Location:613 → 785
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:1496 → 1618
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd00869
      Location:804 → 972
      PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
      pfam00794
      Location:364 → 466
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam13646
      Location:886 → 969
      HEAT_2; HEAT repeats

    2. XM_015119516.2 → XP_014975002.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1

      UniProtKB/TrEMBL
      G7MEU7, H9ESL7
      Related
      ENSMMUP00000078200.1, ENSMMUT00000103362.1
      Conserved Domains (7) summary
      cd00895
      Location:987 → 1340
      PI3Kc_C2_beta; Catalytic domain of Class II Phosphoinositide 3-kinase beta
      cd07290
      Location:1369 → 1477
      PX_PI3K_C2_beta; The phosphoinositide binding Phox Homology Domain of the Beta Isoform of Class II Phosphoinositide 3-Kinases
      cd04012
      Location:622 → 794
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:1505 → 1627
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd00869
      Location:813 → 981
      PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
      pfam00794
      Location:364 → 466
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam13646
      Location:895 → 978
      HEAT_2; HEAT repeats

    3. XM_015119527.2 → XP_014975013.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X3

      UniProtKB/TrEMBL
      G7MEU7
      Conserved Domains (7) summary
      cd00895
      Location:765 → 1118
      PI3Kc_C2_beta; Catalytic domain of Class II Phosphoinositide 3-kinase beta
      cd07290
      Location:1147 → 1255
      PX_PI3K_C2_beta; The phosphoinositide binding Phox Homology Domain of the Beta Isoform of Class II Phosphoinositide 3-Kinases
      cd04012
      Location:400 → 572
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:1283 → 1405
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd00869
      Location:591 → 759
      PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
      pfam00794
      Location:142 → 244
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam13646
      Location:673 → 756
      HEAT_2; HEAT repeats

    4. XM_015119535.2 → XP_014975021.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X4

      UniProtKB/TrEMBL
      A0A1D5QJQ7
      Conserved Domains (5) summary
      cd04012
      Location:622 → 794
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd00869
      Location:813 → 981
      PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
      pfam00794
      Location:364 → 466
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam13646
      Location:895 → 978
      HEAT_2; HEAT repeats
      cl21453
      Location:987 → 1318
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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