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    PTPN11 protein tyrosine phosphatase non-receptor type 11 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 712044, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PTPN11provided by VGNC
    Official Full Name
    protein tyrosine phosphatase non-receptor type 11provided by VGNC
    Primary source
    VGNC:VGNC:100095
    See related
    Ensembl:ENSMMUG00000013253
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    SHP2
    Orthologs
    human mouse all
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    Genomic context

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    See PTPN11 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 11 NC_041764.1 (112131016..112229655)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 11 NC_027903.1 (112443916..112545964)

    Chromosome 11 - NC_041764.1Genomic Context describing neighboring genes Neighboring gene HECT domain E3 ubiquitin protein ligase 4 Neighboring gene ribosomal protein L6 Neighboring gene uncharacterized LOC114671076 Neighboring gene rabphilin 3A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Suppressed Th17 levels correlate with elevated PIAS3, SHP2, and SOCS3 expression in CD4 T cells during acute simian immunodeficiency virus infection. Bixler SL, et al. J Virol, 2013 Jun. PMID 23596301, Free PMC Article
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Suppressed Th17 levels correlated with upregulated expression of negative regulatory genes, PIAS3, SHP2, and SOCS3 in CD4 T cells during acute SIV infection.
      Title: Suppressed Th17 levels correlate with elevated PIAS3, SHP2, and SOCS3 expression in CD4 T cells during acute simian immunodeficiency virus infection.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 11
    Names
    Src homology region 2 domain-containing phosphatase 2
    NP_001248038.1
    XP_015008322.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261109.1 → NP_001248038.1  tyrosine-protein phosphatase non-receptor type 11

      See identical proteins and their annotated locations for NP_001248038.1

      Status: PROVISIONAL

      Source sequence(s)
      JV045239
      UniProtKB/TrEMBL
      F6ZJD8, H9Z053
      Related
      ENSMMUP00000017427.4, ENSMMUT00000018606.4
      Conserved Domains (3) summary
      cd09931
      Location:111 → 218
      SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd10340
      Location:5 → 103
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd14605
      Location:272 → 524
      PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041764.1 Reference Mmul_10 Primary Assembly

      Range
      112131016..112229655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015152836.2 → XP_015008322.1  tyrosine-protein phosphatase non-receptor type 11 isoform X1

      UniProtKB/TrEMBL
      A0A1D5QQ90, H9FXT1
      Related
      ENSMMUP00000050217.2, ENSMMUT00000070469.2
      Conserved Domains (3) summary
      cd09931
      Location:111 → 218
      SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd10340
      Location:5 → 103
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      cd14605
      Location:272 → 528
      PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11
    Nucleotide Protein
    Heading Accession and Version

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