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    PPARG peroxisome proliferator activated receptor gamma [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574190, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PPARGprovided by VGNC
    Official Full Name
    peroxisome proliferator activated receptor gammaprovided by VGNC
    Primary source
    VGNC:VGNC:76229
    See related
    Ensembl:ENSMMUG00000007191
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    PPARGAMMA
    Orthologs
    human mouse all
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    Genomic context

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    See PPARG in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (143655500..143804531)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (53972278..54122777, complement)

    Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene synapsin II Neighboring gene TIMP metallopeptidase inhibitor 4 Neighboring gene glutathione S-transferase Mu 5 pseudogene Neighboring gene 5S ribosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene tRNA splicing endonuclease subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of peroxisome proliferator-activated receptor-gamma in the substantia nigra of hemiparkinsonian nonhuman primates. Swanson C, et al. Neurol Res, 2014 Jul. PMID 24620964, Free PMC Article
    2. Relationships of PPARgamma and PPARgamma2 mRNA levels to obesity, diabetes and hyperinsulinaemia in rhesus monkeys. Hotta K, et al. Int J Obes Relat Metab Disord, 1998 Oct. PMID 9806316
    3. Effects of aleglitazar, a balanced dual peroxisome proliferator-activated receptor α/γ agonist on glycemic and lipid parameters in a primate model of the metabolic syndrome. Hansen BC, et al. Cardiovasc Diabetol, 2011 Jan 20. PMID 21251281, Free PMC Article
    4. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study found PPAR-gamma expression was prominent in the subthalamic nucleus, oculomotor nucleus, ventral tegmental nucleus, and to a lesser extent, in the putamen; 3 or 12 months after MPTP, only the lesioned putamen had increased PPAR-gamma
      Title: Expression of peroxisome proliferator-activated receptor-gamma in the substantia nigra of hemiparkinsonian nonhuman primates.
    2. Aleglitazar, a dual PPARalpha/gamma agonist, has beneficial effects on both lipid and glucose parameters in a primate model of the metabolic syndrome.
      Title: Effects of aleglitazar, a balanced dual peroxisome proliferator-activated receptor α/γ agonist on glycemic and lipid parameters in a primate model of the metabolic syndrome.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in hormone-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peroxisome proliferator-activated receptor gamma
    Names
    PPAR-gamma
    nuclear receptor subfamily 1 group C member 3
    peroxisome proliferator-activated receptor gamma 1-a
    peroxisome proliferator-activated receptor gamma 1-b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032860.1 → NP_001028032.1  peroxisome proliferator-activated receptor gamma

      See identical proteins and their annotated locations for NP_001028032.1

      Status: PROVISIONAL

      Source sequence(s)
      AF033103
      UniProtKB/Swiss-Prot
      O18924, Q9TQW6
      UniProtKB/TrEMBL
      G7MKP9
      Related
      ENSMMUP00000076208.1, ENSMMUT00000100236.1
      Conserved Domains (3) summary
      cd06932
      Location:237 → 504
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:138 → 221
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:31 → 108
      PPARgamma_N; PPAR gamma N-terminal region

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041755.1 Reference Mmul_10 Primary Assembly

      Range
      143655500..143804531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015130200.2 → XP_014985686.1  peroxisome proliferator-activated receptor gamma isoform X2

      UniProtKB/TrEMBL
      G7MKP9
      Related
      ENSMMUP00000041660.2, ENSMMUT00000071107.2
      Conserved Domains (3) summary
      cd06932
      Location:207 → 474
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:108 → 191
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:1 → 78
      PPARgamma_N; PPAR gamma N-terminal region

    2. XM_028843043.1 → XP_028698876.1  peroxisome proliferator-activated receptor gamma isoform X1

      UniProtKB/TrEMBL
      G7MKP9
      Conserved Domains (3) summary
      cd06932
      Location:215 → 482
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:116 → 199
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:9 → 86
      PPARgamma_N; PPAR gamma N-terminal region

    3. XM_028843044.1 → XP_028698877.1  peroxisome proliferator-activated receptor gamma isoform X1

      UniProtKB/TrEMBL
      G7MKP9
      Conserved Domains (3) summary
      cd06932
      Location:215 → 482
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:116 → 199
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:9 → 86
      PPARgamma_N; PPAR gamma N-terminal region

    4. XM_015130199.2 → XP_014985685.1  peroxisome proliferator-activated receptor gamma isoform X2

      UniProtKB/TrEMBL
      G7MKP9
      Conserved Domains (3) summary
      cd06932
      Location:207 → 474
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:108 → 191
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:1 → 78
      PPARgamma_N; PPAR gamma N-terminal region

    5. XM_028843038.1 → XP_028698871.1  peroxisome proliferator-activated receptor gamma isoform X1

      UniProtKB/TrEMBL
      G7MKP9
      Conserved Domains (3) summary
      cd06932
      Location:215 → 482
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:116 → 199
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:9 → 86
      PPARgamma_N; PPAR gamma N-terminal region

    6. XM_028843042.1 → XP_028698875.1  peroxisome proliferator-activated receptor gamma isoform X1

      UniProtKB/TrEMBL
      G7MKP9
      Conserved Domains (3) summary
      cd06932
      Location:215 → 482
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:116 → 199
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:9 → 86
      PPARgamma_N; PPAR gamma N-terminal region

    7. XM_028843041.1 → XP_028698874.1  peroxisome proliferator-activated receptor gamma isoform X1

      UniProtKB/TrEMBL
      G7MKP9
      Conserved Domains (3) summary
      cd06932
      Location:215 → 482
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:116 → 199
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:9 → 86
      PPARgamma_N; PPAR gamma N-terminal region

    8. XM_028843040.1 → XP_028698873.1  peroxisome proliferator-activated receptor gamma isoform X1

      UniProtKB/TrEMBL
      G7MKP9
      Conserved Domains (3) summary
      cd06932
      Location:215 → 482
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:116 → 199
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:9 → 86
      PPARgamma_N; PPAR gamma N-terminal region

    9. XM_015130202.2 → XP_014985688.1  peroxisome proliferator-activated receptor gamma isoform X2

      UniProtKB/TrEMBL
      G7MKP9
      Conserved Domains (3) summary
      cd06932
      Location:207 → 474
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:108 → 191
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:1 → 78
      PPARgamma_N; PPAR gamma N-terminal region

    10. XM_028843045.1 → XP_028698878.1  peroxisome proliferator-activated receptor gamma isoform X3

      Conserved Domains (1) summary
      cd06932
      Location:34 → 265
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18924.1 GenPept UniProtKB/Swiss-Prot:O18924

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