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    PCSK4 proprotein convertase subtilisin/kexin type 4 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 707567, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PCSK4provided by VGNC
    Official Full Name
    proprotein convertase subtilisin/kexin type 4provided by VGNC
    Primary source
    VGNC:VGNC:75786
    See related
    Ensembl:ENSMMUG00000003056
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PCSK4 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (1275852..1285110, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (1284433..1292962, complement)

    Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S15 Neighboring gene APC regulator of WNT signaling pathway 2 Neighboring gene chromosome 19 C19orf25 homolog Neighboring gene receptor accessory protein 6 Neighboring gene ADAMTS like 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptide hormone processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proprotein convertase subtilisin/kexin type 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041772.1 Reference Mmul_10 Primary Assembly

      Range
      1275852..1285110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028838641.1 → XP_028694474.1  proprotein convertase subtilisin/kexin type 4 isoform X8

      Conserved Domains (3) summary
      cd04059
      Location:118 → 441
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:523 → 609
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:37 → 107
      S8_pro-domain; Peptidase S8 pro-domain

    2. XM_028838640.1 → XP_028694473.1  proprotein convertase subtilisin/kexin type 4 isoform X7

      UniProtKB/TrEMBL
      A0A5F8A473
      Related
      ENSMMUP00000072690.1, ENSMMUT00000101013.1
      Conserved Domains (3) summary
      cd04059
      Location:7 → 313
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:553 → 590
      FU; Furin-like repeats
      pfam01483
      Location:395 → 481
      P_proprotein; Proprotein convertase P-domain

    3. XM_028838642.1 → XP_028694475.1  proprotein convertase subtilisin/kexin type 4 isoform X7

      UniProtKB/TrEMBL
      A0A5F8A473
      Conserved Domains (3) summary
      cd04059
      Location:7 → 313
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:553 → 590
      FU; Furin-like repeats
      pfam01483
      Location:395 → 481
      P_proprotein; Proprotein convertase P-domain

    4. XM_015122355.2 → XP_014977841.1  proprotein convertase subtilisin/kexin type 4 isoform X5

      UniProtKB/TrEMBL
      F6VEN2, G7NL53
      Related
      ENSMMUP00000004077.3, ENSMMUT00000004325.4
      Conserved Domains (5) summary
      cd04059
      Location:118 → 407
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:647 → 684
      FU; Furin-like repeats
      pfam00082
      Location:149 → 432
      Peptidase_S8; Subtilase family
      pfam01483
      Location:489 → 575
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:37 → 107
      S8_pro-domain; Peptidase S8 pro-domain

    5. XM_028838636.1 → XP_028694469.1  proprotein convertase subtilisin/kexin type 4 isoform X2

      UniProtKB/TrEMBL
      G7NL53
      Conserved Domains (4) summary
      cd04059
      Location:118 → 432
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:672 → 709
      FU; Furin-like repeats
      pfam01483
      Location:514 → 600
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:37 → 107
      S8_pro-domain; Peptidase S8 pro-domain

    6. XM_028838638.1 → XP_028694471.1  proprotein convertase subtilisin/kexin type 4 isoform X4

      UniProtKB/TrEMBL
      G7NL53
      Conserved Domains (4) summary
      cd04059
      Location:118 → 416
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:656 → 693
      FU; Furin-like repeats
      pfam01483
      Location:498 → 584
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:37 → 107
      S8_pro-domain; Peptidase S8 pro-domain

    7. XM_028838637.1 → XP_028694470.1  proprotein convertase subtilisin/kexin type 4 isoform X3

      UniProtKB/TrEMBL
      G7NL53
      Conserved Domains (4) summary
      cd04059
      Location:118 → 441
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:672 → 709
      FU; Furin-like repeats
      pfam01483
      Location:514 → 600
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:37 → 107
      S8_pro-domain; Peptidase S8 pro-domain

    8. XM_028838635.1 → XP_028694468.1  proprotein convertase subtilisin/kexin type 4 isoform X1

      UniProtKB/TrEMBL
      G7NL53
      Conserved Domains (4) summary
      cd04059
      Location:118 → 441
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:681 → 718
      FU; Furin-like repeats
      pfam01483
      Location:523 → 609
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:37 → 107
      S8_pro-domain; Peptidase S8 pro-domain

    9. XM_028838639.1 → XP_028694472.1  proprotein convertase subtilisin/kexin type 4 isoform X6

      UniProtKB/TrEMBL
      A0A5F8A473
      Conserved Domains (4) summary
      cd04059
      Location:66 → 389
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:629 → 666
      FU; Furin-like repeats
      pfam01483
      Location:471 → 557
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:11 → 55
      S8_pro-domain; Peptidase S8 pro-domain
    Nucleotide Protein
    Heading Accession and Version

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