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    BCR BCR activator of RhoGEF and GTPase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 709258, updated on 17-Aug-2024

    Summary

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    Official Symbol
    BCRprovided by VGNC
    Official Full Name
    BCR activator of RhoGEF and GTPaseprovided by VGNC
    Primary source
    VGNC:VGNC:97739
    See related
    Ensembl:ENSMMUG00000023622
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See BCR in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 10 NC_041763.1 (29210931..29344665, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 10 NC_027902.1 (65127933..65264766)

    Chromosome 10 - NC_041763.1Genomic Context describing neighboring genes Neighboring gene actin-related protein 2 pseudogene Neighboring gene ADP-ribosylation factor-like protein 5A pseudogene Neighboring gene putative POM121-like protein 1 Neighboring gene uncharacterized LOC114670547 Neighboring gene F-box/WD repeat-containing protein 4 pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene U7 small nuclear RNA Neighboring gene RAB36, member RAS oncogene family Neighboring gene radial spoke head 14 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    breakpoint cluster region protein
    Names
    BCR, RhoGEF and GTPase activating protein
    XP_002798337.3
    XP_028684473.1
    XP_028684474.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041763.1 Reference Mmul_10 Primary Assembly

      Range
      29210931..29344665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002798291.3 → XP_002798337.3  breakpoint cluster region protein isoform X1

      UniProtKB/TrEMBL
      F6Y8F5, F7HB27
      Related
      ENSMMUP00000012482.4, ENSMMUT00000013322.4
      Conserved Domains (5) summary
      cd08686
      Location:913 → 1033
      C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
      cd04387
      Location:1052 → 1252
      RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...
      cd13367
      Location:684 → 877
      PH_BCR_vertebrate; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
      pfam00621
      Location:502 → 689
      RhoGEF; RhoGEF domain
      pfam09036
      Location:3 → 75
      Bcr-Abl_Oligo; Bcr-Abl oncoprotein oligomerization domain

    2. XM_028828640.1 → XP_028684473.1  breakpoint cluster region protein isoform X2

      UniProtKB/TrEMBL
      F7HB27
      Conserved Domains (5) summary
      cd08686
      Location:913 → 1033
      C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
      cd00160
      Location:499 → 689
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13367
      Location:684 → 877
      PH_BCR_vertebrate; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
      pfam09036
      Location:3 → 75
      Bcr-Abl_Oligo; Bcr-Abl oncoprotein oligomerization domain
      cl02570
      Location:1052 → 1110
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    3. XM_028828641.1 → XP_028684474.1  breakpoint cluster region protein isoform X3

      UniProtKB/TrEMBL
      F7HB27
      Conserved Domains (4) summary
      cd00160
      Location:499 → 689
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13367
      Location:684 → 877
      PH_BCR_vertebrate; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
      pfam09036
      Location:3 → 75
      Bcr-Abl_Oligo; Bcr-Abl oncoprotein oligomerization domain
      cl14603
      Location:913 → 1004
      C2; C2 domain
    Nucleotide Protein
    Heading Accession and Version

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