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    NRG1 neuregulin 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 696275, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NRG1provided by VGNC
    Official Full Name
    neuregulin 1provided by VGNC
    Primary source
    VGNC:VGNC:75527
    See related
    Ensembl:ENSMMUG00000000208
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See NRG1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 8 NC_041761.1 (31967813..33107858)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 8 NC_027900.1 (31731844..32871307)

    Chromosome 8 - NC_041761.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114680402 Neighboring gene uncharacterized LOC114680221 Neighboring gene uncharacterized LOC114680222 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC114680223

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The expression and localization of neuregulin-1 (Nrg1) in the gastrointestinal system of the rhesus monkey. Zhao WJ. Folia Histochem Cytobiol, 2013. PMID 23690216
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables chemorepellent activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in animal organ development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pro-neuregulin-1, membrane-bound isoform

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041761.1 Reference Mmul_10 Primary Assembly

      Range
      31967813..33107858
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028852553.1 → XP_028708386.1  pro-neuregulin-1, membrane-bound isoform isoform X8

      Conserved Domains (3) summary
      pfam00008
      Location:404 → 434
      EGF; EGF-like domain
      pfam02158
      Location:486 → 643
      Neuregulin; Neuregulin family
      cd05895
      Location:251 → 343
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

    2. XM_028852554.1 → XP_028708387.1  pro-neuregulin-1, membrane-bound isoform isoform X9

      Conserved Domains (3) summary
      PHA03099
      Location:396 → 485
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
      pfam02158
      Location:478 → 635
      Neuregulin; Neuregulin family
      cd05895
      Location:251 → 343
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

    3. XM_015145144.2 → XP_015000630.2  pro-neuregulin-1, membrane-bound isoform isoform X3

      Conserved Domains (3) summary
      cd05895
      Location:267 → 341
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam02158
      Location:420 → 813
      Neuregulin; Neuregulin family
      pfam00008
      Location:370 → 400
      EGF; EGF-like domain

    4. XM_028852552.1 → XP_028708385.1  pro-neuregulin-1, membrane-bound isoform isoform X4

      Conserved Domains (3) summary
      cd05895
      Location:267 → 341
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam02158
      Location:412 → 805
      Neuregulin; Neuregulin family
      pfam00008
      Location:370 → 400
      EGF; EGF-like domain

    5. XM_015145137.2 → XP_015000623.2  pro-neuregulin-1, membrane-bound isoform isoform X1

      Conserved Domains (3) summary
      cd05895
      Location:267 → 341
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam02158
      Location:454 → 847
      Neuregulin; Neuregulin family
      pfam00008
      Location:404 → 434
      EGF; EGF-like domain

    6. XM_028852550.1 → XP_028708383.1  pro-neuregulin-1, membrane-bound isoform isoform X2

      Conserved Domains (3) summary
      cd05895
      Location:267 → 341
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam02158
      Location:446 → 839
      Neuregulin; Neuregulin family
      pfam00008
      Location:404 → 434
      EGF; EGF-like domain

    7. XM_028852555.1 → XP_028708388.1  pro-neuregulin-1, membrane-bound isoform isoform X14

      UniProtKB/TrEMBL
      F7HH60
      Conserved Domains (3) summary
      cd05895
      Location:12 → 86
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam02158
      Location:199 → 592
      Neuregulin; Neuregulin family
      pfam00008
      Location:149 → 179
      EGF; EGF-like domain

    8. XM_015145142.2 → XP_015000628.2  pro-neuregulin-1, membrane-bound isoform isoform X11

      UniProtKB/TrEMBL
      A0A5F8AIH5, G7MZ25
      Related
      ENSMMUP00000076768.1, ENSMMUT00000107593.1
      Conserved Domains (3) summary
      cd05895
      Location:53 → 127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam02158
      Location:235 → 628
      Neuregulin; Neuregulin family
      pfam00008
      Location:190 → 220
      EGF; EGF-like domain

    9. XM_015145143.2 → XP_015000629.2  pro-neuregulin-1, membrane-bound isoform isoform X12

      UniProtKB/TrEMBL
      G7MZ25
      Conserved Domains (3) summary
      cd05895
      Location:53 → 127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam02158
      Location:232 → 625
      Neuregulin; Neuregulin family
      pfam00008
      Location:190 → 220
      EGF; EGF-like domain

    10. XM_015145146.2 → XP_015000632.2  pro-neuregulin-1, membrane-bound isoform isoform X19

      UniProtKB/TrEMBL
      F6S993
      Related
      ENSMMUP00000032156.3, ENSMMUT00000039073.3
      Conserved Domains (3) summary
      cd05895
      Location:53 → 127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam02158
      Location:235 → 424
      Neuregulin; Neuregulin family
      pfam00008
      Location:190 → 220
      EGF; EGF-like domain

    11. XM_015145141.2 → XP_015000627.2  pro-neuregulin-1, membrane-bound isoform isoform X10

      UniProtKB/TrEMBL
      F7HH69, G7MZ25
      Related
      ENSMMUP00000000295.4, ENSMMUT00000000312.4
      Conserved Domains (3) summary
      cd05895
      Location:53 → 127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam02158
      Location:240 → 633
      Neuregulin; Neuregulin family
      pfam00008
      Location:190 → 220
      EGF; EGF-like domain

    12. XM_015145147.2 → XP_015000633.2  pro-neuregulin-1, membrane-bound isoform isoform X20

      Conserved Domains (3) summary
      cd05895
      Location:53 → 127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      PHA03099
      Location:182 → 271
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
      pfam02158
      Location:232 → 421
      Neuregulin; Neuregulin family

    13. XM_015145145.2 → XP_015000631.2  pro-neuregulin-1, membrane-bound isoform isoform X13

      UniProtKB/TrEMBL
      A0A5F8A4P6, F7HH60
      Related
      ENSMMUP00000071878.1, ENSMMUT00000090865.1
      Conserved Domains (3) summary
      cd05895
      Location:53 → 127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam02158
      Location:206 → 599
      Neuregulin; Neuregulin family
      pfam00008
      Location:156 → 186
      EGF; EGF-like domain

    14. XM_015145150.2 → XP_015000636.2  pro-neuregulin-1, membrane-bound isoform isoform X22

      UniProtKB/TrEMBL
      A0A5F8APY7
      Related
      ENSMMUP00000078981.1, ENSMMUT00000091263.1
      Conserved Domains (2) summary
      cd05895
      Location:53 → 127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam00008
      Location:190 → 220
      EGF; EGF-like domain

    15. XM_028852556.1 → XP_028708389.1  pro-neuregulin-1, membrane-bound isoform isoform X15

      Conserved Domains (1) summary
      pfam02158
      Location:327 → 484
      Neuregulin; Neuregulin family

    16. XM_015145139.2 → XP_015000625.2  pro-neuregulin-1, membrane-bound isoform isoform X6

      UniProtKB/TrEMBL
      A0A5F7ZK62
      Conserved Domains (2) summary
      pfam02158
      Location:290 → 683
      Neuregulin; Neuregulin family
      pfam00008
      Location:245 → 275
      EGF; EGF-like domain

    17. XM_015145138.2 → XP_015000624.2  pro-neuregulin-1, membrane-bound isoform isoform X5

      UniProtKB/TrEMBL
      A0A5F7ZFK0, A0A5F7ZK62
      Related
      ENSMMUP00000064397.1, ENSMMUT00000110119.1
      Conserved Domains (2) summary
      pfam02158
      Location:295 → 688
      Neuregulin; Neuregulin family
      pfam00008
      Location:245 → 275
      EGF; EGF-like domain

    18. XM_015145140.2 → XP_015000626.2  pro-neuregulin-1, membrane-bound isoform isoform X7

      UniProtKB/TrEMBL
      A0A1D5RJA6, A0A5F7ZK62
      Related
      ENSMMUP00000060400.2, ENSMMUT00000071014.2
      Conserved Domains (2) summary
      pfam02158
      Location:287 → 680
      Neuregulin; Neuregulin family
      pfam00008
      Location:245 → 275
      EGF; EGF-like domain

    19. XM_015145148.2 → XP_015000634.1  pro-neuregulin-1, membrane-bound isoform isoform X21

      Conserved Domains (3) summary
      PHA03099
      Location:28 → 120
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
      cd00054
      Location:36 → 68
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam02158
      Location:113 → 270
      Neuregulin; Neuregulin family

    20. XM_028852558.1 → XP_028708391.1  pro-neuregulin-1, membrane-bound isoform isoform X17

      UniProtKB/TrEMBL
      F7HH60
      Conserved Domains (2) summary
      pfam02158
      Location:81 → 474
      Neuregulin; Neuregulin family
      pfam00008
      Location:36 → 66
      EGF; EGF-like domain

    21. XM_028852557.1 → XP_028708390.1  pro-neuregulin-1, membrane-bound isoform isoform X16

      UniProtKB/TrEMBL
      F7HH60
      Conserved Domains (2) summary
      pfam02158
      Location:86 → 479
      Neuregulin; Neuregulin family
      pfam00008
      Location:36 → 66
      EGF; EGF-like domain

    22. XM_028852559.1 → XP_028708392.1  pro-neuregulin-1, membrane-bound isoform isoform X18

      UniProtKB/TrEMBL
      F7HH60
      Conserved Domains (2) summary
      pfam02158
      Location:78 → 471
      Neuregulin; Neuregulin family
      pfam00008
      Location:36 → 66
      EGF; EGF-like domain
    Nucleotide Protein
    Heading Accession and Version

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