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    PLCG1 phospholipase C gamma 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 697069, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PLCG1provided by VGNC
    Official Full Name
    phospholipase C gamma 1provided by VGNC
    Primary source
    VGNC:VGNC:76169
    See related
    Ensembl:ENSMMUG00000005905
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PLCG1 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 10 NC_041763.1 (76396244..76435203)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 10 NC_027902.1 (22716953..22756429, complement)

    Chromosome 10 - NC_041763.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114670479 Neighboring gene U2 spliceosomal RNA Neighboring gene DNA topoisomerase I Neighboring gene zinc fingers and homeoboxes 3 Neighboring gene lipin 3 Neighboring gene elastin microfibril interfacer 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of epithelial cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
    Names
    1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
    XP_015004490.1
    XP_015004491.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041763.1 Reference Mmul_10 Primary Assembly

      Range
      76396244..76435203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015149004.2 → XP_015004490.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1

      UniProtKB/TrEMBL
      A0A1D5R8E9, A0A1D5RKE8
      Related
      ENSMMUP00000056589.2, ENSMMUT00000075401.2
      Conserved Domains (10) summary
      smart00149
      Location:954 → 1069
      PLCYc; Phospholipase C, catalytic domain (part); domain Y
      cd00275
      Location:1087 → 1211
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08592
      Location:319 → 466
      PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
      cd09932
      Location:663 → 765
      SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
      cd10341
      Location:545 → 649
      SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
      cd11970
      Location:791 → 850
      SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
      cd13234
      Location:864 → 933
      PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
      cd13362
      Location:29 → 151
      PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
      pfam00169
      Location:71 → 142
      PH; PH domain
      cl17171
      Location:489 → 523
      PH-like; Pleckstrin homology-like domain

    2. XM_015149005.2 → XP_015004491.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2

      UniProtKB/TrEMBL
      A0A1D5RKE8
      Conserved Domains (10) summary
      smart00149
      Location:954 → 1069
      PLCYc; Phospholipase C, catalytic domain (part); domain Y
      cd00275
      Location:1087 → 1211
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08592
      Location:319 → 466
      PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
      cd09932
      Location:663 → 765
      SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
      cd10341
      Location:545 → 649
      SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
      cd11970
      Location:791 → 850
      SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
      cd13234
      Location:864 → 933
      PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
      cd13362
      Location:29 → 151
      PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
      pfam00169
      Location:71 → 142
      PH; PH domain
      cl17171
      Location:489 → 523
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version

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