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    TIMP2 TIMP metallopeptidase inhibitor 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574357, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TIMP2provided by VGNC
    Official Full Name
    TIMP metallopeptidase inhibitor 2provided by VGNC
    Primary source
    VGNC:VGNC:99300
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    TIMP-2
    Orthologs
    human mouse all
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    Genomic context

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    See TIMP2 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 16 NC_041769.1 (75177672..75249178, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 16 NC_027908.1 (72670541..72691124, complement)

    Chromosome 16 - NC_041769.1Genomic Context describing neighboring genes Neighboring gene cytohesin 1 Neighboring gene ubiquitin specific peptidase 36 Neighboring gene CEP295 N-terminal like Neighboring gene galectin 3 binding protein Neighboring gene calcium activated nucleotidase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protease binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metalloproteinase inhibitor 2
    Names
    tissue inhibitor of matrix metalloproteinase-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041769.1 Reference Mmul_10 Primary Assembly

      Range
      75177672..75249178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028836870.1 → XP_028692703.1  metalloproteinase inhibitor 2 isoform X1

      UniProtKB/TrEMBL
      H9FBZ7, H9YV73
      Conserved Domains (1) summary
      cd03585
      Location:27 → 209
      NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

    2. XM_028836873.1 → XP_028692706.1  metalloproteinase inhibitor 2 isoform X4

      UniProtKB/TrEMBL
      G7NH08
      Conserved Domains (1) summary
      cl02512
      Location:1 → 132
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

    3. XM_028836872.1 → XP_028692705.1  metalloproteinase inhibitor 2 isoform X3

      UniProtKB/TrEMBL
      G7NH08
      Conserved Domains (1) summary
      cd03585
      Location:2 → 166
      NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

    4. XM_028836871.1 → XP_028692704.1  metalloproteinase inhibitor 2 isoform X2

      UniProtKB/TrEMBL
      G7NH08
      Conserved Domains (1) summary
      cd03585
      Location:12 → 176
      NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...
    Nucleotide Protein
    Heading Accession and Version

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