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    MAPK10 mitogen-activated protein kinase 10 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 699736, updated on 17-Aug-2024

    Summary

    Official Symbol
    MAPK10provided by VGNC
    Official Full Name
    mitogen-activated protein kinase 10provided by VGNC
    Primary source
    VGNC:VGNC:81469
    Locus tag
    EGK_15898
    See related
    Ensembl:ENSMMUG00000008342
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Summary
    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MAPK10 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 5 NC_041758.1 (84406993..84744880, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 5 NC_027897.1 (84357819..84695908, complement)

    Chromosome 5 - NC_041758.1Genomic Context describing neighboring genes Neighboring gene deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial pseudogene Neighboring gene defective in cullin neddylation 1 domain containing 4 Neighboring gene Rho GTPase activating protein 24 Neighboring gene uncharacterized LOC106998403 Neighboring gene uncharacterized LOC114678348 Neighboring gene uncharacterized LOC106998405

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables JUN kinase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    mitogen-activated protein kinase 10
    NP_001247786.1
    NP_001307491.1
    NP_001307492.1
    XP_014994213.1
    XP_014994214.1
    XP_014994215.1
    XP_014994216.1
    XP_014994219.1
    XP_014994220.1
    XP_014994221.1
    XP_014994222.1
    XP_014994223.1
    XP_014994225.1
    XP_028703850.1
    XP_028703851.1
    XP_028703852.1
    XP_028703853.1
    XP_028703854.1
    XP_028703855.1
    XP_028703856.1
    XP_028703857.1
    XP_028703858.1
    XP_028703859.1
    XP_028703860.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001260857.2NP_001247786.1  mitogen-activated protein kinase 10 isoform 1

      See identical proteins and their annotated locations for NP_001247786.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (1).
      Source sequence(s)
      JU320450, JV489638, JV527909, JV668676, JV703991
      UniProtKB/TrEMBL
      A0A1D5Q2A9, A0A1D5QMC7, A0A8J8YAK3, G7MTC3
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    2. NM_001320562.1NP_001307491.1  mitogen-activated protein kinase 10 isoform 1x

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
      Source sequence(s)
      JU320450, JV489638, JV527909, JV668676, JV703991
      UniProtKB/TrEMBL
      F7HRW7
      Conserved Domains (2) summary
      smart00220
      Location:64359
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    3. NM_001320563.1NP_001307492.1  mitogen-activated protein kinase 10 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate donor splice site in the 5' region, which results in translation initiation from an in-frame, downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      JU320450, JV489638, JV527909, JV668675, JV703991
      UniProtKB/TrEMBL
      F6UVD6, F7HRW7, H9EP96
      Related
      ENSMMUP00000010941.3, ENSMMUT00000011669.4
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041758.1 Reference Mmul_10 Primary Assembly

      Range
      84406993..84744880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015138730.2XP_014994216.1  mitogen-activated protein kinase 10 isoform X2

      UniProtKB/TrEMBL
      F7GN93
      Related
      ENSMMUP00000002307.4, ENSMMUT00000002439.4
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    2. XM_015138737.2XP_014994223.1  mitogen-activated protein kinase 10 isoform X6

      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    3. XM_028848024.1XP_028703857.1  mitogen-activated protein kinase 10 isoform X4

      UniProtKB/TrEMBL
      A0A1D5QS39
      Related
      ENSMMUP00000050867.2, ENSMMUT00000075045.2
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    4. XM_028848023.1XP_028703856.1  mitogen-activated protein kinase 10 isoform X3

      UniProtKB/TrEMBL
      F6UVD6, F7HRW7, H9EP96
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    5. XM_028848018.1XP_028703851.1  mitogen-activated protein kinase 10 isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q2A9, A0A1D5QMC7, A0A8J8YAK3, G7MTC3
      Related
      ENSMMUP00000042171.2, ENSMMUT00000058821.2
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    6. XM_015138727.2XP_014994213.1  mitogen-activated protein kinase 10 isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q2A9, A0A1D5QMC7, A0A8J8YAK3, G7MTC3
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    7. XM_015138733.2XP_014994219.1  mitogen-activated protein kinase 10 isoform X3

      UniProtKB/TrEMBL
      F6UVD6, F7HRW7, H9EP96
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    8. XM_028848017.1XP_028703850.1  mitogen-activated protein kinase 10 isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q2A9, A0A1D5QMC7, A0A8J8YAK3, G7MTC3
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    9. XM_028848021.1XP_028703854.1  mitogen-activated protein kinase 10 isoform X3

      UniProtKB/TrEMBL
      F6UVD6, F7HRW7, H9EP96
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    10. XM_028848022.1XP_028703855.1  mitogen-activated protein kinase 10 isoform X3

      UniProtKB/TrEMBL
      F6UVD6, F7HRW7, H9EP96
      Related
      ENSMMUP00000035034.3, ENSMMUT00000042031.3
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    11. XM_015138729.2XP_014994215.1  mitogen-activated protein kinase 10 isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q2A9, A0A1D5QMC7, A0A8J8YAK3, G7MTC3
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    12. XM_015138735.2XP_014994221.1  mitogen-activated protein kinase 10 isoform X3

      UniProtKB/TrEMBL
      F6UVD6, F7HRW7, H9EP96
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    13. XM_028848019.1XP_028703852.1  mitogen-activated protein kinase 10 isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q2A9, A0A1D5QMC7, A0A8J8YAK3, G7MTC3
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    14. XM_015138728.2XP_014994214.1  mitogen-activated protein kinase 10 isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q2A9, A0A1D5QMC7, A0A8J8YAK3, G7MTC3
      Related
      ENSMMUP00000049202.2, ENSMMUT00000071834.2
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    15. XM_015138734.2XP_014994220.1  mitogen-activated protein kinase 10 isoform X3

      UniProtKB/TrEMBL
      F6UVD6, F7HRW7, H9EP96
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    16. XM_028848020.1XP_028703853.1  mitogen-activated protein kinase 10 isoform X3

      UniProtKB/TrEMBL
      F6UVD6, F7HRW7, H9EP96
      Related
      ENSMMUP00000074401.1, ENSMMUT00000095981.1
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    17. XM_028848027.1XP_028703860.1  mitogen-activated protein kinase 10 isoform X8

      Conserved Domains (1) summary
      cd07850
      Location:1284
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    18. XM_015138736.2XP_014994222.1  mitogen-activated protein kinase 10 isoform X5

      UniProtKB/TrEMBL
      F7HRW9
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    19. XM_028848026.1XP_028703859.1  mitogen-activated protein kinase 10 isoform X7

      UniProtKB/TrEMBL
      A0A5F8AKY4
      Related
      ENSMMUP00000077699.1, ENSMMUT00000105819.1
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    20. XM_028848025.1XP_028703858.1  mitogen-activated protein kinase 10 isoform X5

      UniProtKB/TrEMBL
      F7HRW9
      Related
      ENSMMUP00000010940.4, ENSMMUT00000011667.4
      Conserved Domains (1) summary
      cd07850
      Location:63398
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    21. XM_015138739.2XP_014994225.1  mitogen-activated protein kinase 10 isoform X9

      Conserved Domains (1) summary
      cl21453
      Location:63248
      PKc_like; Protein Kinases, catalytic domain