FASLG Fas ligand [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: FASLGprovided by VGNC
Official Full Name: Fas ligandprovided by VGNC
Primary source: VGNC:VGNC:106364
See related: Ensembl:ENSMMUG00000065134
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as: FASL; CD95L; CD95-L; TNFSF6
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	1	NC_041754.1 (29964034..29970894)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	1	NC_027893.1 (194887013..194893873, complement)

Chromosome 1 - NC_041754.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The present results may provide some insights to understand the role of Fas/FasL in the spinal cord but not motor cortex with neuronal apoptosis and neuroplasticity in monkeys subjected to hemisection spinal cord injury.
Title: Fas and FasL expression in the spinal cord following cord hemisection in the monkey.

Submit: New GeneRIF Correction

General gene information

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Markers

PMC86001P1 (e-PCR)
- UniSTS:273502

PMC86001P2 (e-PCR)
- UniSTS:273503

PMC135646P4 (e-PCR)
- UniSTS:270768

D1S3209 (e-PCR)
- UniSTS:75969

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tumor necrosis factor ligand superfamily member 6

Names: CD95 ligand; FAS antigen CD95; fas antigen ligand

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001032838.1 → NP_001028010.1 tumor necrosis factor ligand superfamily member 6

See identical proteins and their annotated locations for NP_001028010.1

Status: PROVISIONAL

Source sequence(s)

AF344856

UniProtKB/TrEMBL

G7MFC6

Related

ENSMMUP00000009549.4, ENSMMUT00000010176.4

Conserved Domains (1) summary

cd00184
Location:145 → 278

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...