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    MTMR6 myotubularin related protein 6 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 709118, updated on 20-Oct-2024

    Summary

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    Official Symbol
    MTMR6provided by VGNC
    Official Full Name
    myotubularin related protein 6provided by VGNC
    Primary source
    VGNC:VGNC:75075
    Locus tag
    EGK_09181
    See related
    Ensembl:ENSMMUG00000018419
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See MTMR6 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 17 NC_041770.1 (4718084..4774973, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 17 NC_027909.1 (4945564..4986989, complement)

    Chromosome 17 - NC_041770.1Genomic Context describing neighboring genes Neighboring gene poly(A) binding protein cytoplasmic 3 Neighboring gene APC membrane recruitment protein 2 Neighboring gene nucleoporin 58 Neighboring gene ATPase phospholipid transporting 8A2 Neighboring gene U6 spliceosomal RNA Neighboring gene inorganic pyrophosphatase 2, mitochondrial pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. miR-190b is markedly upregulated in the intestine in response to simian immunodeficiency virus replication and partly regulates myotubularin-related protein-6 expression. Mohan M, et al. J Immunol, 2014 Aug 1. PMID 24981450, Free PMC Article
    2. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    3. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Luciferase reporter assays confirm MTMR6 as a direct miR-190b target; miR-190b-mediated MTMR6 downregulation suggests an important mechanism that could keep infected cells in an activated state, thereby promoting viral replication.
      Title: miR-190b is markedly upregulated in the intestine in response to simian immunodeficiency virus replication and partly regulates myotubularin-related protein-6 expression.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables phosphatidylinositol-3,5-bisphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6; myotubularin-related protein 6
    Names
    Myotubularin-related protein 6
    NP_001253944.1
    XP_014976198.1
    XP_028692974.1
    XP_028692975.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267015.1 → NP_001253944.1  phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6

      See identical proteins and their annotated locations for NP_001253944.1

      Status: PROVISIONAL

      Source sequence(s)
      JV044687
      UniProtKB/TrEMBL
      A0A8J8YSN0, F6XZI9, G7NJT0, H9G1M5
      Related
      ENSMMUP00000068583.1, ENSMMUT00000110287.1
      Conserved Domains (2) summary
      cd13343
      Location:1 → 101
      PH-GRAM_MTMR6; Myotubularian (MTM) related (MTMR) 6 protein Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd14585
      Location:130 → 431
      PTP-MTMR6; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 6

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041770.1 Reference Mmul_10 Primary Assembly

      Range
      4718084..4774973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028837141.1 → XP_028692974.1  myotubularin-related protein 6 isoform X1

      UniProtKB/TrEMBL
      F6XZI9
      Conserved Domains (2) summary
      cl17171
      Location:37 → 130
      PH-like; Pleckstrin homology-like domain
      cl28904
      Location:159 → 498
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    2. XM_028837142.1 → XP_028692975.1  myotubularin-related protein 6 isoform X3

      UniProtKB/TrEMBL
      F6XZG8, F6XZI9
      Related
      ENSMMUP00000036472.3, ENSMMUT00000043470.3
      Conserved Domains (2) summary
      cd14585
      Location:159 → 460
      PTP-MTMR6; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 6
      cl17171
      Location:37 → 130
      PH-like; Pleckstrin homology-like domain

    3. XM_015120712.2 → XP_014976198.1  myotubularin-related protein 6 isoform X2

      UniProtKB/TrEMBL
      F6XZI9
      Conserved Domains (2) summary
      cd13343
      Location:1 → 101
      PH-GRAM_MTMR6; Myotubularian (MTM) related (MTMR) 6 protein Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam06602
      Location:107 → 482
      Myotub-related; Myotubularin-like phosphatase domain
    Nucleotide Protein
    Heading Accession and Version

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