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    APPL2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 701612, updated on 17-Aug-2024

    Summary

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    Official Symbol
    APPL2provided by VGNC
    Official Full Name
    adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2provided by VGNC
    Primary source
    VGNC:VGNC:69861
    See related
    Ensembl:ENSMMUG00000009524
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See APPL2 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 11 NC_041764.1 (104920575..104982876, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 11 NC_027903.1 (105121575..105183628, complement)

    Chromosome 11 - NC_041764.1Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 1 family member L2 Neighboring gene WASH complex subunit 4 Neighboring gene uncharacterized LOC114670939 Neighboring gene chromosome 11 C12orf75 homolog Neighboring gene kallikrein-13 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DCC-interacting protein 13-beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041764.1 Reference Mmul_10 Primary Assembly

      Range
      104920575..104982876 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015152662.2 → XP_015008148.1  DCC-interacting protein 13-beta isoform X2

      UniProtKB/TrEMBL
      A0A5F7ZH24
      Related
      ENSMMUP00000012457.4, ENSMMUT00000013291.4
      Conserved Domains (4) summary
      cd13158
      Location:415 → 548
      PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
      cd13247
      Location:185 → 309
      BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain
      pfam00169
      Location:211 → 308
      PH; PH domain
      cl12013
      Location:1 → 167
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_028829821.1 → XP_028685654.1  DCC-interacting protein 13-beta isoform X1

      UniProtKB/TrEMBL
      H9EUV7, I0FJ95
      Related
      ENSMMUP00000069407.1, ENSMMUT00000100039.1
      Conserved Domains (3) summary
      cd07632
      Location:20 → 234
      BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
      cd13158
      Location:482 → 615
      PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
      cd13247
      Location:252 → 376
      BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain

    3. XM_028829822.1 → XP_028685655.1  DCC-interacting protein 13-beta isoform X3

      UniProtKB/TrEMBL
      H9EUV7
      Conserved Domains (3) summary
      cd07632
      Location:20 → 234
      BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
      cd13158
      Location:482 → 615
      PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
      cd13247
      Location:252 → 376
      BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain
    Nucleotide Protein
    Heading Accession and Version

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