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    PDE4D phosphodiesterase 4D [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 712180, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PDE4Dprovided by VGNC
    Official Full Name
    phosphodiesterase 4Dprovided by VGNC
    Primary source
    VGNC:VGNC:75917
    See related
    Ensembl:ENSMMUG00000012132
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PDE4D in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 6 NC_041759.1 (57315151..58848161, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 6 NC_027898.1 (48631320..49955154, complement)

    Chromosome 6 - NC_041759.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114678793 Neighboring gene RAB3C, member RAS oncogene family Neighboring gene uncharacterized LOC106998750 Neighboring gene uncharacterized LOC106998746 Neighboring gene surfeit locus protein 1 pseudogene Neighboring gene uncharacterized LOC114679015 Neighboring gene uncharacterized LOC114679016 Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 pseudogene Neighboring gene U2 spliceosomal RNA Neighboring gene microRNA mir-582 Neighboring gene uncharacterized LOC114679017 Neighboring gene U6 spliceosomal RNA Neighboring gene protein SET pseudogene Neighboring gene uncharacterized LOC106998748 Neighboring gene uncharacterized LOC713151 Neighboring gene DEP domain containing 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATPase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cAMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of cAMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cardiac muscle cell contraction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cAMP-specific 3',5'-cyclic phosphodiesterase 4D
    Names
    phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
    XP_001101097.3
    XP_002804419.2
    XP_002804421.2
    XP_014995495.1
    XP_014995496.1
    XP_014995498.1
    XP_014995499.1
    XP_014995500.1
    XP_028705892.1
    XP_028705893.1
    XP_028705894.1
    XP_028705895.1
    XP_028705896.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041759.1 Reference Mmul_10 Primary Assembly

      Range
      57315151..58848161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028850059.1 → XP_028705892.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

      UniProtKB/TrEMBL
      G7MTT0
      Conserved Domains (2) summary
      pfam00233
      Location:400 → 641
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:162 → 278
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    2. XM_015140012.2 → XP_014995498.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

      UniProtKB/TrEMBL
      G7MTT0
      Conserved Domains (2) summary
      pfam00233
      Location:400 → 641
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:162 → 278
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    3. XM_015140010.2 → XP_014995496.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

      UniProtKB/TrEMBL
      G7MTT0
      Conserved Domains (2) summary
      pfam00233
      Location:400 → 641
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:162 → 278
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    4. XM_015140013.2 → XP_014995499.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X4

      UniProtKB/TrEMBL
      G7MTT0
      Conserved Domains (2) summary
      pfam00233
      Location:390 → 631
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:152 → 268
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    5. XM_015140009.2 → XP_014995495.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1

      UniProtKB/TrEMBL
      F7GZT2, G7MTT0
      Related
      ENSMMUP00000015921.3, ENSMMUT00000016999.4
      Conserved Domains (2) summary
      pfam00233
      Location:461 → 702
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:223 → 339
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    6. XM_002804373.3 → XP_002804419.2  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X3

      UniProtKB/TrEMBL
      G7MTT0
      Conserved Domains (2) summary
      pfam00233
      Location:397 → 638
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:159 → 275
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    7. XM_028850061.1 → XP_028705894.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X7

      UniProtKB/TrEMBL
      G7MTT0
      Conserved Domains (2) summary
      pfam00233
      Location:325 → 566
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:87 → 203
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    8. XM_028850063.1 → XP_028705896.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X9

      UniProtKB/TrEMBL
      H9FB80
      Conserved Domains (2) summary
      pfam00233
      Location:205 → 446
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:1 → 83
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    9. XM_028850060.1 → XP_028705893.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X5

      UniProtKB/TrEMBL
      G7MTT0
      Conserved Domains (2) summary
      pfam00233
      Location:351 → 592
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:113 → 229
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    10. XM_001101097.4 → XP_001101097.3  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X8

      UniProtKB/TrEMBL
      F7GZV4, G7MTT0
      Related
      ENSMMUP00000015918.2, ENSMMUT00000016996.3
      Conserved Domains (2) summary
      pfam00233
      Location:339 → 580
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:101 → 217
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    11. XM_002804375.3 → XP_002804421.2  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X6

      UniProtKB/TrEMBL
      F7GZV2, G7MTT0
      Related
      ENSMMUP00000015919.4, ENSMMUT00000016997.4
      Conserved Domains (2) summary
      pfam00233
      Location:331 → 572
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:93 → 209
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    12. XM_028850062.1 → XP_028705895.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X9

      UniProtKB/TrEMBL
      H9FB80
      Conserved Domains (2) summary
      pfam00233
      Location:205 → 446
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:1 → 83
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    13. XM_015140014.2 → XP_014995500.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X10

      UniProtKB/TrEMBL
      H9FB80
      Conserved Domains (2) summary
      pfam00233
      Location:159 → 400
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:1 → 37
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    Nucleotide Protein
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