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    RASGRP1 RAS guanyl releasing protein 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 703838, updated on 17-Aug-2024

    Summary

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    Official Symbol
    RASGRP1provided by VGNC
    Official Full Name
    RAS guanyl releasing protein 1provided by VGNC
    Primary source
    VGNC:VGNC:76671
    See related
    Ensembl:ENSMMUG00000018333
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See RASGRP1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (14913188..14991106, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (14821016..14899043, complement)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene sprouty related EVH1 domain containing 1 Neighboring gene family with sequence similarity 98 member B Neighboring gene uncharacterized LOC114679254 Neighboring gene long intergenic non-protein coding RNA 2694

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RAS guanyl-releasing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      14913188..14991106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001092164.4 → XP_001092164.1  RAS guanyl-releasing protein 1 isoform X3

      UniProtKB/TrEMBL
      F6TUV4, G7MWM0
      Related
      ENSMMUP00000033864.3, ENSMMUT00000040838.3
      Conserved Domains (6) summary
      smart00147
      Location:201 → 437
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:54 → 175
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      pfam00130
      Location:542 → 591
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:478 → 526
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:474 → 521
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl21462
      Location:734 → 780
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    2. XM_002804715.3 → XP_002804761.1  RAS guanyl-releasing protein 1 isoform X4

      UniProtKB/TrEMBL
      G7MWM0
      Related
      ENSMMUP00000024105.4, ENSMMUT00000025766.4
      Conserved Domains (6) summary
      smart00147
      Location:192 → 428
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:45 → 166
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      pfam00130
      Location:533 → 582
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:469 → 517
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:465 → 512
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl21462
      Location:725 → 771
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    3. XM_028850726.1 → XP_028706559.1  RAS guanyl-releasing protein 1 isoform X1

      UniProtKB/TrEMBL
      G7MWM0
      Conserved Domains (4) summary
      smart00147
      Location:201 → 437
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:54 → 175
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      pfam00130
      Location:542 → 591
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:478 → 527
      EF-hand_7; EF-hand domain pair

    4. XM_028850727.1 → XP_028706560.1  RAS guanyl-releasing protein 1 isoform X2

      UniProtKB/TrEMBL
      G7MWM0
      Conserved Domains (4) summary
      smart00147
      Location:153 → 389
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:6 → 127
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      pfam00130
      Location:494 → 543
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:430 → 479
      EF-hand_7; EF-hand domain pair
    Nucleotide Protein
    Heading Accession and Version

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