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    NF2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 714945, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NF2provided by VGNC
    Official Full Name
    NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressorprovided by VGNC
    Primary source
    VGNC:VGNC:75324
    See related
    Ensembl:ENSMMUG00000010311
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See NF2 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 10 NC_041763.1 (21851049..21952119, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 10 NC_027902.1 (71421621..71525611)

    Chromosome 10 - NC_041763.1Genomic Context describing neighboring genes Neighboring gene cytochrome b-c1 complex subunit 9 Neighboring gene zinc finger matrin-type 5 Neighboring gene calcium binding protein 7 Neighboring gene ribulose-phosphate 3-epimerase-like Neighboring gene nipsnap homolog 1 Neighboring gene THO complex subunit 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cell adhesion molecule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of early endosome to late endosome transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to early endosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of gliogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of organelle assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in apical part of cell IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    merlin
    Names
    neurofibromin 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001266255.1 → NP_001253184.1  merlin

      See identical proteins and their annotated locations for NP_001253184.1

      Status: PROVISIONAL

      Source sequence(s)
      JV564983
      UniProtKB/TrEMBL
      F6RPW5, H9EPK9
      Related
      ENSMMUP00000013508.4, ENSMMUT00000014420.4
      Conserved Domains (6) summary
      smart00295
      Location:23 → 222
      B41; Band 4.1 homologues
      cd13194
      Location:216 → 312
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00373
      Location:107 → 222
      FERM_M; FERM central domain
      pfam00769
      Location:347 → 595
      ERM; Ezrin/radixin/moesin family
      pfam09379
      Location:26 → 87
      FERM_N; FERM N-terminal domain
      cl02098
      Location:334 → 487
      14-3-3; 14-3-3 domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041763.1 Reference Mmul_10 Primary Assembly

      Range
      21851049..21952119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015150000.2 → XP_015005486.1  merlin isoform X1

      UniProtKB/TrEMBL
      F6RI41, F6RPZ9, H9EPL0
      Related
      ENSMMUP00000013505.4, ENSMMUT00000014417.4
      Conserved Domains (4) summary
      PLN03086
      Location:307 → 367
      PLN03086; PRLI-interacting factor K; Provisional
      smart00295
      Location:23 → 222
      B41; Band 4.1 homologues
      cd13194
      Location:216 → 312
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:347 → 579
      ERM; Ezrin/radixin/moesin family

    2. XM_015150001.2 → XP_015005487.1  merlin isoform X1

      UniProtKB/TrEMBL
      F6RI41, F6RPZ9, H9EPL0
      Conserved Domains (4) summary
      PLN03086
      Location:307 → 367
      PLN03086; PRLI-interacting factor K; Provisional
      smart00295
      Location:23 → 222
      B41; Band 4.1 homologues
      cd13194
      Location:216 → 312
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:347 → 579
      ERM; Ezrin/radixin/moesin family

    3. XM_028827379.1 → XP_028683212.1  merlin isoform X3

      UniProtKB/TrEMBL
      H9EPL0
      Conserved Domains (4) summary
      PLN03086
      Location:307 → 367
      PLN03086; PRLI-interacting factor K; Provisional
      smart00295
      Location:23 → 222
      B41; Band 4.1 homologues
      cd13194
      Location:216 → 312
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:347 → 479
      ERM; Ezrin/radixin/moesin family

    4. XM_028827378.1 → XP_028683211.1  merlin isoform X2

      UniProtKB/TrEMBL
      F6RPV5, H9EPL0
      Related
      ENSMMUP00000013509.4, ENSMMUT00000014421.4
      Conserved Domains (4) summary
      PLN03086
      Location:307 → 367
      PLN03086; PRLI-interacting factor K; Provisional
      smart00295
      Location:23 → 222
      B41; Band 4.1 homologues
      cd13194
      Location:216 → 312
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:347 → 524
      ERM; Ezrin/radixin/moesin family
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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