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    PTPN22 protein tyrosine phosphatase non-receptor type 22 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 707433, updated on 17-Aug-2024

    Summary

    Official Symbol
    PTPN22provided by VGNC
    Official Full Name
    protein tyrosine phosphatase non-receptor type 22provided by VGNC
    Primary source
    VGNC:VGNC:76603
    See related
    Ensembl:ENSMMUG00000006786
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    NEW
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    Genomic context

    See PTPN22 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (110344474..110409428)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (114846301..114911374, complement)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 4 subunit beta 1 Neighboring gene DNA cross-link repair 1B Neighboring gene BCL2 like 15 Neighboring gene uncharacterized LOC107000335 Neighboring gene round spermatid basic protein 1 Neighboring gene putative homeodomain transcription factor 1

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in negative regulation of T cell activation IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in negative regulation of p38MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in negative regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in peptidyl-tyrosine dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in positive regulation of CD8-positive, alpha-beta T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in positive regulation of defense response to virus by host IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in positive regulation of granzyme B production IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in positive regulation of protein K63-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in positive regulation of toll-like receptor 3 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in positive regulation of toll-like receptor 4 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in positive regulation of toll-like receptor 7 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in positive regulation of toll-like receptor 9 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in regulation of T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in regulation of non-canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    tyrosine-protein phosphatase non-receptor type 22
    NP_001248005.1
    XP_015002651.2
    XP_015002655.2
    XP_015002665.2
    XP_015002667.2
    XP_028699185.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261076.1NP_001248005.1  tyrosine-protein phosphatase non-receptor type 22

      See identical proteins and their annotated locations for NP_001248005.1

      Status: PROVISIONAL

      Source sequence(s)
      JU470960
      UniProtKB/TrEMBL
      F7H1J1, H9YVP8
      Related
      ENSMMUP00000008924.3, ENSMMUT00000009494.4
      Conserved Domains (2) summary
      smart00194
      Location:24288
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:56288
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      110344474..110409428
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015147169.2XP_015002655.2  tyrosine-protein phosphatase non-receptor type 22 isoform X3

      UniProtKB/TrEMBL
      A0A1D5QSG6, F7H1J1
      Related
      ENSMMUP00000050994.2, ENSMMUT00000073226.2
      Conserved Domains (1) summary
      cd14602
      Location:57290
      PTPc-N22; catalytic domain of tyrosine-protein phosphatase non-receptor type 22
    2. XM_015147179.2XP_015002665.2  tyrosine-protein phosphatase non-receptor type 22 isoform X4

      UniProtKB/TrEMBL
      F7H1J1
      Related
      ENSMMUP00000063970.1, ENSMMUT00000085323.1
      Conserved Domains (1) summary
      cd14602
      Location:57290
      PTPc-N22; catalytic domain of tyrosine-protein phosphatase non-receptor type 22
    3. XM_028843352.1XP_028699185.1  tyrosine-protein phosphatase non-receptor type 22 isoform X1

      UniProtKB/TrEMBL
      F7H1J1
      Conserved Domains (1) summary
      cd14602
      Location:57290
      PTPc-N22; catalytic domain of tyrosine-protein phosphatase non-receptor type 22
    4. XM_015147165.2XP_015002651.2  tyrosine-protein phosphatase non-receptor type 22 isoform X2

      UniProtKB/TrEMBL
      F7H1J1
      Conserved Domains (1) summary
      cl28904
      Location:57264
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    5. XM_015147181.2XP_015002667.2  tyrosine-protein phosphatase non-receptor type 22 isoform X5

      UniProtKB/TrEMBL
      F7H1J1
      Conserved Domains (1) summary
      cl28904
      Location:57250
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily