U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CD209 CD209 molecule [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574211, updated on 6-Oct-2023

    Summary

    Go to the top of the page Help
    Gene symbol
    CD209
    Gene description
    CD209 molecule
    See related
    Ensembl:ENSMMUG00000022463
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    DC-SIGN
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CD209 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (7686682..7691096, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (7948861..7953275, complement)

    Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene C-type lectin CD209L2 Neighboring gene U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 pseudogene Neighboring gene C-type lectin domain family 4 member G-like Neighboring gene uncharacterized LOC114674058

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Tissue-specific reduction in DC-SIGN expression correlates with progression of pathogenic simian immunodeficiency virus infection. Yearley JH, et al. Dev Comp Immunol, 2008. PMID 18606180
    2. Selective distribution and pregnancy-specific expression of DC-SIGN at the maternal-fetal interface in the rhesus macaque: DC-SIGN is a putative marker of the recognition of pregnancy. Breburda EE, et al. Placenta, 2006 Jan. PMID 16310033
    3. Gene for chinese rhesus macaque DC-SIGN predicts the existence of A but not B isoforms of the protein. Santos PR, et al. AIDS Res Hum Retroviruses, 2002 Sep 1. PMID 12230940
    4. Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN. Wu L, et al. Proc Natl Acad Sci U S A, 2002 Feb 5. PMID 11818554, Free PMC Article
    5. Rhesus macaque and chimpanzee DC-SIGN act as HIV/SIV gp120 trans-receptors, similar to human DC-SIGN. Geijtenbeek TB, et al. Immunol Lett, 2001 Nov 1. PMID 11595296

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DC-SIGN expression in mesenteric lymph nodes is significantly downregulated in simian immunodeficiency virus-infected pig-tailed macaques.
      Title: Tissue-specific reduction in DC-SIGN expression correlates with progression of pathogenic simian immunodeficiency virus infection.
    2. DC-SIGN+ cells showed a clear differential distribution in the decidua in the first 2 weeks of pregnancy, being found only adjacent to the implantation site
      Title: Selective distribution and pregnancy-specific expression of DC-SIGN at the maternal-fetal interface in the rhesus macaque: DC-SIGN is a putative marker of the recognition of pregnancy.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    General protein information

    Go to the top of the page Help
    Preferred Names
    CD209 antigen
    Names
    DC-SIGN1
    dendritic cell-specific ICAM-3 grabbing non-integrin
    dendritic cell-specific ICAM-3-grabbing non-integrin 1
    putative mannose-binding C-type lectin mDC-SIGN

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032870.1 → NP_001028042.1  CD209 antigen isoform 1

      See identical proteins and their annotated locations for NP_001028042.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF391086
      UniProtKB/Swiss-Prot
      Q8HXL6, Q8HXL7, Q8HXL8, Q8HXL9, Q8SQB2, Q95J96, Q95LA8
      Related
      ENSMMUP00000029557.4, ENSMMUT00000031593.4
      Conserved Domains (1) summary
      cd03590
      Location:256 → 379
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

    2. NM_001033089.1 → NP_001028261.1  CD209 antigen isoform 2

      See identical proteins and their annotated locations for NP_001028261.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AF369755
      UniProtKB/TrEMBL
      A5X2X8, A5X2Y5
      Conserved Domains (2) summary
      cd03590
      Location:233 → 356
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      cl03855
      Location:42 → 149
      CemA; CemA family

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041772.1 Reference Mmul_10 Primary Assembly

      Range
      7686682..7691096 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95J96.2 GenPept UniProtKB/Swiss-Prot:Q95J96

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials