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    HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 697155, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HECW2provided by VGNC
    Official Full Name
    HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2provided by VGNC
    Primary source
    VGNC:VGNC:73257
    Locus tag
    EGK_04643
    See related
    Ensembl:ENSMMUG00000005627
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See HECW2 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 12 NC_041765.1 (83335009..83721942, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (149847606..150235439)

    Chromosome 12 - NC_041765.1Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 7 Neighboring gene transcription factor E2F3-like Neighboring gene small nucleolar RNA U13 Neighboring gene serine/threonine kinase 17b Neighboring gene uncharacterized LOC106997077 Neighboring gene small Cajal body-specific RNA 16 Neighboring gene coiled-coil domain containing 150

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of sodium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HECW2
    Names
    e3 ubiquitin-protein ligase HECW2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041765.1 Reference Mmul_10 Primary Assembly

      Range
      83335009..83721942 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015131908.2 → XP_014987394.1  E3 ubiquitin-protein ligase HECW2 isoform X1

      UniProtKB/TrEMBL
      A0A663DCI9, A0A8J8YT85, F6WD73, G7N8J7
      Conserved Domains (7) summary
      cd08691
      Location:185 → 321
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      PHA03307
      Location:319 → 737
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00078
      Location:1216 → 1570
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02063
      Location:670 → 810
      MARCKS; MARCKS family
      pfam05466
      Location:506 → 701
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      pfam16562
      Location:45 → 164
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam00397
      Location:809 → 838
      WW; WW domain

    2. XM_015131906.2 → XP_014987392.1  E3 ubiquitin-protein ligase HECW2 isoform X1

      UniProtKB/TrEMBL
      A0A663DCI9, A0A8J8YT85, F6WD73, G7N8J7
      Conserved Domains (7) summary
      cd08691
      Location:185 → 321
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      PHA03307
      Location:319 → 737
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00078
      Location:1216 → 1570
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02063
      Location:670 → 810
      MARCKS; MARCKS family
      pfam05466
      Location:506 → 701
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      pfam16562
      Location:45 → 164
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam00397
      Location:809 → 838
      WW; WW domain

    3. XM_028830948.1 → XP_028686781.1  E3 ubiquitin-protein ligase HECW2 isoform X1

      UniProtKB/TrEMBL
      A0A663DCI9, A0A8J8YT85, F6WD73, G7N8J7
      Conserved Domains (7) summary
      cd08691
      Location:185 → 321
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      PHA03307
      Location:319 → 737
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00078
      Location:1216 → 1570
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02063
      Location:670 → 810
      MARCKS; MARCKS family
      pfam05466
      Location:506 → 701
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      pfam16562
      Location:45 → 164
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam00397
      Location:809 → 838
      WW; WW domain

    4. XM_028830947.1 → XP_028686780.1  E3 ubiquitin-protein ligase HECW2 isoform X1

      UniProtKB/TrEMBL
      A0A663DCI9, A0A8J8YT85, F6WD73, G7N8J7
      Conserved Domains (7) summary
      cd08691
      Location:185 → 321
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      PHA03307
      Location:319 → 737
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00078
      Location:1216 → 1570
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02063
      Location:670 → 810
      MARCKS; MARCKS family
      pfam05466
      Location:506 → 701
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      pfam16562
      Location:45 → 164
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam00397
      Location:809 → 838
      WW; WW domain

    5. XM_028830950.1 → XP_028686783.1  E3 ubiquitin-protein ligase HECW2 isoform X1

      UniProtKB/TrEMBL
      A0A663DCI9, A0A8J8YT85, F6WD73, G7N8J7
      Conserved Domains (7) summary
      cd08691
      Location:185 → 321
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      PHA03307
      Location:319 → 737
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00078
      Location:1216 → 1570
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02063
      Location:670 → 810
      MARCKS; MARCKS family
      pfam05466
      Location:506 → 701
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      pfam16562
      Location:45 → 164
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam00397
      Location:809 → 838
      WW; WW domain

    6. XM_015131909.2 → XP_014987395.1  E3 ubiquitin-protein ligase HECW2 isoform X2

      Conserved Domains (7) summary
      cd08691
      Location:54 → 190
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00119
      Location:1109 → 1438
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1085 → 1439
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:678 → 707
      WW; WW domain
      pfam12429
      Location:370 → 528
      DUF3676; Protein of unknown function (DUF3676)
      pfam12446
      Location:549 → 644
      DUF3682; Protein of unknown function (DUF3682)
      pfam16562
      Location:1 → 33
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    7. XM_015131907.2 → XP_014987393.1  E3 ubiquitin-protein ligase HECW2 isoform X1

      UniProtKB/TrEMBL
      A0A663DCI9, A0A8J8YT85, F6WD73, G7N8J7
      Related
      ENSMMUP00000007439.3, ENSMMUT00000007914.4
      Conserved Domains (7) summary
      cd08691
      Location:185 → 321
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      PHA03307
      Location:319 → 737
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00078
      Location:1216 → 1570
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02063
      Location:670 → 810
      MARCKS; MARCKS family
      pfam05466
      Location:506 → 701
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      pfam16562
      Location:45 → 164
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
      pfam00397
      Location:809 → 838
      WW; WW domain
    Nucleotide Protein
    Heading Accession and Version

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