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    KCNH2 potassium voltage-gated channel subfamily H member 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 714174, updated on 17-Aug-2024

    Summary

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    Official Symbol
    KCNH2provided by VGNC
    Official Full Name
    potassium voltage-gated channel subfamily H member 2provided by VGNC
    Primary source
    VGNC:VGNC:73980
    See related
    Ensembl:ENSMMUG00000020436
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See KCNH2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (176946491..176979854, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (177166227..177199587, complement)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene U6 snRNA-associated Sm-like protein LSm3 Neighboring gene amine oxidase copper containing 1 Neighboring gene uncharacterized LOC100424674 Neighboring gene nitric oxide synthase 3 Neighboring gene autophagy related 9B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables inward rectifier potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in membrane repolarization during action potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of heart rate by cardiac conduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of ventricular cardiac muscle cell membrane repolarization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    potassium voltage-gated channel subfamily H member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      176946491..176979854 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015135279.2 → XP_014990765.2  potassium voltage-gated channel subfamily H member 2 isoform X2

      UniProtKB/TrEMBL
      F6WEC3, F6WEE3
      Related
      ENSMMUP00000026900.4, ENSMMUT00000028748.4
      Conserved Domains (4) summary
      cd00038
      Location:742 → 853
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam15836
      Location:1012 → 1113
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
      pfam00520
      Location:409 → 668
      Ion_trans; Ion transport protein
      pfam13426
      Location:29 → 130
      PAS_9; PAS domain

    2. XM_015135282.2 → XP_014990768.1  potassium voltage-gated channel subfamily H member 2 isoform X6

      UniProtKB/TrEMBL
      F6WED3
      Related
      ENSMMUP00000026901.2, ENSMMUT00000028749.4
      Conserved Domains (5) summary
      COG0664
      Location:396 → 516
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:402 → 513
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:109 → 328
      Ion_trans; Ion transport protein
      pfam07885
      Location:271 → 325
      Ion_trans_2; Ion channel
      pfam15836
      Location:672 → 773
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

    3. XM_028846469.1 → XP_028702302.1  potassium voltage-gated channel subfamily H member 2 isoform X4

      UniProtKB/TrEMBL
      F6WEC3
      Conserved Domains (4) summary
      cd00038
      Location:720 → 831
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam15836
      Location:990 → 1086
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
      pfam00520
      Location:409 → 648
      Ion_trans; Ion transport protein
      pfam13426
      Location:29 → 130
      PAS_9; PAS domain

    4. XM_028846467.1 → XP_028702300.1  potassium voltage-gated channel subfamily H member 2 isoform X1

      UniProtKB/TrEMBL
      F6WEC3
      Conserved Domains (4) summary
      cd00038
      Location:742 → 853
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam15836
      Location:1012 → 1108
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
      pfam00520
      Location:409 → 668
      Ion_trans; Ion transport protein
      pfam13426
      Location:29 → 130
      PAS_9; PAS domain

    5. XM_028846468.1 → XP_028702301.1  potassium voltage-gated channel subfamily H member 2 isoform X3

      UniProtKB/TrEMBL
      F6WEC3
      Conserved Domains (4) summary
      cd00038
      Location:729 → 840
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam15836
      Location:999 → 1095
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
      pfam00520
      Location:396 → 655
      Ion_trans; Ion transport protein
      pfam13426
      Location:16 → 117
      PAS_9; PAS domain

    6. XM_028846470.1 → XP_028702303.1  potassium voltage-gated channel subfamily H member 2 isoform X5

      UniProtKB/TrEMBL
      G7MNG1
      Conserved Domains (3) summary
      cd00038
      Location:742 → 853
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:409 → 668
      Ion_trans; Ion transport protein
      pfam13426
      Location:29 → 130
      PAS_9; PAS domain
    Nucleotide Protein
    Heading Accession and Version

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