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    PDE4A phosphodiesterase 4A [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 712850, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PDE4Aprovided by VGNC
    Official Full Name
    phosphodiesterase 4Aprovided by VGNC
    Primary source
    VGNC:VGNC:75915
    See related
    Ensembl:ENSMMUG00000016122
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PDE4A in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (10177784..10231870)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (10455100..10506928)

    Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene intercellular adhesion molecule 3 Neighboring gene tyrosine kinase 2 Neighboring gene cell division cycle 37, HSP90 cochaperone Neighboring gene kelch like ECH associated protein 1 Neighboring gene sphingosine-1-phosphate receptor 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cAMP-specific 3',5'-cyclic phosphodiesterase 4A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041772.1 Reference Mmul_10 Primary Assembly

      Range
      10177784..10231870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028839945.1 → XP_028695778.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X2

      UniProtKB/TrEMBL
      F6X2M7, F6Z5W6
      Related
      ENSMMUP00000031854.3, ENSMMUT00000038773.3
      Conserved Domains (1) summary
      pfam00233
      Location:410 → 651
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    2. XM_015122853.2 → XP_014978339.2  cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1

      UniProtKB/TrEMBL
      F6X2P4, H9F4I4
      Related
      ENSMMUP00000031853.3, ENSMMUT00000038772.3
      Conserved Domains (1) summary
      pfam00233
      Location:432 → 673
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    3. XM_015122854.2 → XP_014978340.2  cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X3

      UniProtKB/TrEMBL
      A0A1D5QCM2, H9F4I4
      Related
      ENSMMUP00000045791.2, ENSMMUT00000056815.2
      Conserved Domains (1) summary
      pfam00233
      Location:406 → 647
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    4. XM_015122855.2 → XP_014978341.2  cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X4

      UniProtKB/TrEMBL
      F7FQP4, H9F4I4, H9FVH8
      Related
      ENSMMUP00000021205.4, ENSMMUT00000022667.4
      Conserved Domains (1) summary
      pfam00233
      Location:371 → 612
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    5. XM_028839946.1 → XP_028695779.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X5

      UniProtKB/TrEMBL
      F7ASN2
      Related
      ENSMMUP00000006657.4, ENSMMUT00000007085.4
      Conserved Domains (2) summary
      pfam00233
      Location:193 → 434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:22 → 54
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    Nucleotide Protein
    Heading Accession and Version

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