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    ZAP70 zeta chain of T cell receptor associated protein kinase 70 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 707555, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ZAP70provided by VGNC
    Official Full Name
    zeta chain of T cell receptor associated protein kinase 70provided by VGNC
    Primary source
    VGNC:VGNC:78822
    See related
    Ensembl:ENSMMUG00000021545
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See ZAP70 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 13 NC_041766.1 (1427377..1454134)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 13 NC_027905.1 (92830489..92857508)

    Chromosome 13 - NC_041766.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene chromosome 13 C2orf92 homolog Neighboring gene actin related protein 1B Neighboring gene transmembrane protein 131 Neighboring gene U7 small nuclear RNA Neighboring gene von Willebrand factor A domain containing 3B Neighboring gene ATP synthase subunit beta, mitochondrial pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extrinsic component of cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase ZAP-70
    Names
    zeta-chain (TCR) associated protein kinase 70kDa
    XP_014968406.1
    XP_028688033.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041766.1 Reference Mmul_10 Primary Assembly

      Range
      1427377..1454134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015112920.2 → XP_014968406.1  tyrosine-protein kinase ZAP-70 isoform X1

      UniProtKB/TrEMBL
      F7FAI7, G7NAQ0
      Related
      ENSMMUP00000028374.3, ENSMMUT00000030321.4
      Conserved Domains (3) summary
      cd09938
      Location:8 → 111
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10402
      Location:152 → 256
      SH2_C-SH2_Zap70; C-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70)
      cd05115
      Location:333 → 601
      PTKc_Zap-70; Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa

    2. XM_028832200.1 → XP_028688033.1  tyrosine-protein kinase ZAP-70 isoform X2

      Conserved Domains (2) summary
      cd05115
      Location:173 → 441
      PTKc_Zap-70; Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa
      cl15255
      Location:1 → 96
      SH2; Src homology 2 (SH2) domain
    Nucleotide Protein
    Heading Accession and Version

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