MAMU-DMA major histocompatibility complex, class II, DM alpha [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Gene symbol: MAMU-DMA
Gene description: major histocompatibility complex, class II, DM alpha
See related: Ensembl:ENSMMUG00000022626
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	4	NC_041757.1 (136569873..136574594)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	4	NC_027896.1 (33775931..33781380, complement)

Chromosome 4 - NC_041757.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables MHC class II protein complex binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immunoglobulin production involved in immunoglobulin-mediated immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in peptide antigen assembly with MHC class II protein complex	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of T cell activation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of MHC class II protein complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: major histocompatibility complex, class II, DM alpha

Names: HLA class II histocompatibility antigen, DM alpha chain; MHC class II protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001193474.1 → NP_001180403.1 major histocompatibility complex, class II, DM alpha precursor

See identical proteins and their annotated locations for NP_001180403.1

Status: VALIDATED

Source sequence(s)

CO725887, CO726452

UniProtKB/TrEMBL

F6VL34

Related

ENSMMUP00000033926.3, ENSMMUT00000040897.3

Conserved Domains (2) summary

cd05767
Location:126 → 218

IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain

smart00920
Location:41 → 123

MHC_II_alpha; Class II histocompatibility antigen, alpha domain

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041757.1 Reference Mmul_10 Primary Assembly

Range

136569873..136574594

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015136062.2 → XP_014991548.2 major histocompatibility complex, class II, DM alpha isoform X1

UniProtKB/TrEMBL

F6VL34

Conserved Domains (2) summary

smart00920
Location:41 → 123

MHC_II_alpha; Class II histocompatibility antigen, alpha domain

cl11960
Location:121 → 184

Ig; Immunoglobulin domain