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    NGEF neuronal guanine nucleotide exchange factor [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 713917, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NGEFprovided by VGNC
    Official Full Name
    neuronal guanine nucleotide exchange factorprovided by VGNC
    Primary source
    VGNC:VGNC:75345
    See related
    Ensembl:ENSMMUG00000012216
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See NGEF in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 12 NC_041765.1 (120318012..120454297, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 12 NC_027904.1 (115409945..115543790, complement)

    Chromosome 12 - NC_041765.1Genomic Context describing neighboring genes Neighboring gene GRB10 interacting GYF protein 2 Neighboring gene U6 spliceosomal RNA Neighboring gene secondary ossification center associated regulator of chondrocyte maturation Neighboring gene uncharacterized LOC114671440 Neighboring gene neuraminidase 2 Neighboring gene inositol polyphosphate-5-phosphatase D Neighboring gene uncharacterized LOC114671442

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ephexin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041765.1 Reference Mmul_10 Primary Assembly

      Range
      120318012..120454297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028831238.1 → XP_028687071.1  ephexin-1 isoform X2

      UniProtKB/TrEMBL
      A0A1D5REE7, F6VMG6, H9FSI9
      Related
      ENSMMUP00000058690.2, ENSMMUT00000071621.2
      Conserved Domains (3) summary
      cd11939
      Location:523 → 577
      SH3_ephexin1; Src homology 3 domain of the Rho guanine nucleotide exchange factor, ephexin-1 (also called NGEF or ARHGEF27)
      cd01221
      Location:384 → 510
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:184 → 362
      RhoGEF; RhoGEF domain

    2. XM_001114604.4 → XP_001114604.1  ephexin-1 isoform X1

      UniProtKB/TrEMBL
      A0A1D5R9A9, G7N973
      Related
      ENSMMUP00000056900.2, ENSMMUT00000054517.2
      Conserved Domains (4) summary
      cd11939
      Location:618 → 672
      SH3_ephexin1; Src homology 3 domain of the Rho guanine nucleotide exchange factor, ephexin-1 (also called NGEF or ARHGEF27)
      cd01221
      Location:479 → 605
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00169
      Location:492 → 598
      PH; PH domain
      pfam00621
      Location:279 → 458
      RhoGEF; RhoGEF domain

    3. XM_028831239.1 → XP_028687072.1  ephexin-1 isoform X3

      UniProtKB/TrEMBL
      F6VMG6
      Conserved Domains (3) summary
      cd11939
      Location:457 → 511
      SH3_ephexin1; Src homology 3 domain of the Rho guanine nucleotide exchange factor, ephexin-1 (also called NGEF or ARHGEF27)
      cd01221
      Location:318 → 444
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:118 → 296
      RhoGEF; RhoGEF domain

    4. XM_028831240.1 → XP_028687073.1  ephexin-1 isoform X3

      UniProtKB/TrEMBL
      F6VMG6
      Related
      ENSMMUP00000016020.3, ENSMMUT00000017106.4
      Conserved Domains (3) summary
      cd11939
      Location:457 → 511
      SH3_ephexin1; Src homology 3 domain of the Rho guanine nucleotide exchange factor, ephexin-1 (also called NGEF or ARHGEF27)
      cd01221
      Location:318 → 444
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:118 → 296
      RhoGEF; RhoGEF domain
    Nucleotide Protein
    Heading Accession and Version

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