Lama4 laminin, alpha 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lama4provided by MGI
Official Full Name: laminin, alpha 4provided by MGI
Primary source: MGI:MGI:109321
See related: Ensembl:ENSMUSG00000019846 AllianceGenome:MGI:109321
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable signaling receptor binding activity. Predicted to be an extracellular matrix structural constituent. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within blood vessel development and brown fat cell differentiation. Located in basement membrane. Is active in neuromuscular junction and synaptic cleft. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1JJ. Orthologous to human LAMA4 (laminin subunit alpha 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 25.5), subcutaneous fat pad adult (RPKM 21.8) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B1; 10 20.02 cM

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (38841511..38986184)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (38965515..39110188)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lymph node fibroblastic reticular cells preserve a tolerogenic niche in allograft transplantation through laminin alpha4.
Title: Lymph node fibroblastic reticular cells preserve a tolerogenic niche in allograft transplantation through laminin α4.
Critical role of Lama4 for hematopoiesis regeneration and acute myeloid leukemia progression.
Title: Critical role of Lama4 for hematopoiesis regeneration and acute myeloid leukemia progression.
Laminin-alpha4 Is Upregulated in Both Human and Murine Models of Obesity.
Title: Laminin-α4 Is Upregulated in Both Human and Murine Models of Obesity.
LAMA4 upregulation is associated with high liver metastasis potential and poor survival outcome of Pancreatic Cancer.
Title: LAMA4 upregulation is associated with high liver metastasis potential and poor survival outcome of Pancreatic Cancer.
Laminin alpha2, alpha4, and alpha5 Chains Positively Regulate Migration and Survival of Oligodendrocyte Precursor Cells.
Title: Laminin α2, α4, and α5 Chains Positively Regulate Migration and Survival of Oligodendrocyte Precursor Cells.
In diverse models, laminins alpha-4 (LAMA4) and alpha-5 (LAMA5) were differentially regulated. Immunity was associated with decreased LAMA4:LAMA5 ratio, while tolerance was associated with an increased ratio. LAMA4inhibited CD4+ T-cell proliferation and Th1, Th2, and Th17 polarization but favored Treg induction. LAMA4 and LAMA5 are coinhibitory and costimulatory ligands for human and mouse CD4 T cells, respectively.
Title: Differential Regulation of T-cell Immunity and Tolerance by Stromal Laminin Expressed in the Lymph Node.
Data (including data from studies in knockout mice) suggest that Lama4 is involved in regulation of energy metabolism, regulation of adiposity, and development of beige adipose tissue; here, Lama4 knockout mice exhibit significantly improved insulin sensitivity compared with wild-type mice, suggesting improved metabolic function.
Title: The Absence of Laminin α4 in Male Mice Results in Enhanced Energy Expenditure and Increased Beige Subcutaneous Adipose Tissue.
Results showed maintained perturbed transmission properties at lama4(-/-) NMJs from adult (3 months) through to aged (18-22 months). Hind-limb grip force demonstrated similar trends as transmission properties, with maintained weaker grip force across age groups in lama4(-/-). Interestingly, both transmission properties and hind-limb grip force in aged wild-types resembled those observed in adult lama4(-/-).
Title: Functional decline at the aging neuromuscular junction is associated with altered laminin-α4 expression.
Lama4-/- NMJs demonstrated a decrease in miniature end-plate potential (EPP) frequency and increased amplitude of miniature EPPs and evoked EPPs.
Title: Loss of laminin-α4 results in pre- and postsynaptic modifications at the neuromuscular junction.
laminin alpha4 influences adipose tissue structure and function in a depot-specific manner.
Title: Laminin α4 deficient mice exhibit decreased capacity for adipose tissue expansion and weight gain.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brown fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in regulation of embryonic development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic cleft	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: laminin subunit alpha-4

Names: laminin [a]4; laminin-14 subunit alpha; laminin-8 subunit alpha; laminin-9 subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010681.4 → NP_034811.2 laminin subunit alpha-4 precursor

See identical proteins and their annotated locations for NP_034811.2

Status: VALIDATED

Source sequence(s)

AC118224, AC153958, BC115942

Consensus CDS

CCDS35882.1

UniProtKB/Swiss-Prot

O88785, P70409, P97927, Q14BF2

Related

ENSMUSP00000019992.6, ENSMUST00000019992.6

Conserved Domains (6) summary

smart00282
Location:853 → 1008

LamG; Laminin G domain

cd00055
Location:187 → 238

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:1482 → 1617

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam06008
Location:289 → 547

Laminin_I; Laminin Domain I

pfam06009
Location:727 → 854

Laminin_II; Laminin Domain II

cl21509
Location:610 → 787

ApoLp-III_like; Apolipophorin-III and similar insect proteins