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    TOP1 DNA topoisomerase I [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 697300, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TOP1provided by VGNC
    Official Full Name
    DNA topoisomerase Iprovided by VGNC
    Primary source
    VGNC:VGNC:78619
    See related
    Ensembl:ENSMMUG00000011112
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See TOP1 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 10 NC_041763.1 (76289529..76392874)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 10 NC_027902.1 (22759812..22863150, complement)

    Chromosome 10 - NC_041763.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107000402 Neighboring gene uncharacterized LOC114670479 Neighboring gene U2 spliceosomal RNA Neighboring gene phospholipase C gamma 1 Neighboring gene zinc fingers and homeoboxes 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in DNA topological change IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA topoisomerase 1
    Names
    topoisomerase (DNA) I
    NP_001253441.1
    XP_015004477.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001266512.2 → NP_001253441.1  DNA topoisomerase 1

      See identical proteins and their annotated locations for NP_001253441.1

      Status: PROVISIONAL

      Source sequence(s)
      JV048105
      UniProtKB/TrEMBL
      F6TZC2, H9FZ51, I2CU74
      Conserved Domains (2) summary
      smart00435
      Location:362 → 739
      TOPEUc; DNA Topoisomerase I (eukaryota)
      pfam02919
      Location:217 → 431
      Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041763.1 Reference Mmul_10 Primary Assembly

      Range
      76289529..76392874
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015148991.2 → XP_015004477.1  DNA topoisomerase 1 isoform X1

      UniProtKB/TrEMBL
      F6TZC2, H9FZ51, I2CU74
      Related
      ENSMMUP00000014547.4, ENSMMUT00000015533.4
      Conserved Domains (2) summary
      smart00435
      Location:362 → 739
      TOPEUc; DNA Topoisomerase I (eukaryota)
      pfam02919
      Location:217 → 431
      Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment
    Nucleotide Protein
    Heading Accession and Version

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