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    NR1I2 nuclear receptor subfamily 1 group I member 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574226, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NR1I2provided by VGNC
    Official Full Name
    nuclear receptor subfamily 1 group I member 2provided by VGNC
    Primary source
    VGNC:VGNC:75507
    See related
    Ensembl:ENSMMUG00000001976
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    PXR
    Orthologs
    human mouse all
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    Genomic context

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    See NR1I2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (156457379..156467606, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (40967813..40978063)

    Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene microRNA mir-6529 Neighboring gene glycogen synthase kinase 3 beta Neighboring gene presenilins-associated rhomboid-like protein, mitochondrial pseudogene Neighboring gene prohibitin pseudogene Neighboring gene cilia and flagella associated protein 91

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors. Moore LB, et al. Mol Endocrinol, 2002 May. PMID 11981033
    2. Analysis of the Macaca mulatta transcriptome and the sequence divergence between Macaca and human. Magness CL, et al. Genome Biol, 2005. PMID 15998449, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear receptor subfamily 1 group I member 2
    Names
    orphan nuclear receptor PXR
    pregnane X receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032882.3 → NP_001028054.3  nuclear receptor subfamily 1 group I member 2

      See identical proteins and their annotated locations for NP_001028054.3

      Status: VALIDATED

      Source sequence(s)
      AF454671
      UniProtKB/Swiss-Prot
      Q8SQ01
      UniProtKB/TrEMBL
      A0A5S6RAZ2, A0A8J8XCK4, F6VGK2, G7MKE8
      Related
      ENSMMUP00000002638.2, ENSMMUT00000002794.3
      Conserved Domains (2) summary
      cd06934
      Location:143 → 428
      NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
      cl02596
      Location:40 → 127
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041755.1 Reference Mmul_10 Primary Assembly

      Range
      156457379..156467606 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SQ01.1 GenPept UniProtKB/Swiss-Prot:Q8SQ01

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    Research Materials