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    IRF3 interferon regulatory factor 3 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 718970, updated on 17-Aug-2024

    Summary

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    Official Symbol
    IRF3provided by VGNC
    Official Full Name
    interferon regulatory factor 3provided by VGNC
    Primary source
    VGNC:VGNC:73761
    See related
    Ensembl:ENSMMUG00000022735
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See IRF3 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (49629971..49637050, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (45075255..45082149, complement)

    Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene RAS related Neighboring gene SR-related CTD associated factor 1 Neighboring gene BCL2 like 12 Neighboring gene protein arginine methyltransferase 1 Neighboring gene adrenomedullin 5 (putative)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Papain-Like Protease of Porcine Reproductive and Respiratory Syndrome Virus Impedes STING Translocation from the Endoplasmic Reticulum to the Golgi Apparatus by Deubiquitinating STIM1. Diao F, et al. J Virol, 2023 Apr 27. PMID 37039642, Free PMC Article
    2. Hepatitis A virus protein 2B suppresses beta interferon (IFN) gene transcription by interfering with IFN regulatory factor 3 activation. Paulmann D, et al. J Gen Virol, 2008 Jul. PMID 18559929
    3. Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections. Mandl JN, et al. Nat Med, 2008 Oct. PMID 18806803
    4. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hepatitis A virus protein 2B suppresses beta interferon (IFN) gene transcription by interfering with IFN regulatory factor 3 activation.
      Title: Hepatitis A virus protein 2B suppresses beta interferon (IFN) gene transcription by interfering with IFN regulatory factor 3 activation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in immune system process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interferon regulatory factor 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135797.1 → NP_001129269.1  interferon regulatory factor 3

      See identical proteins and their annotated locations for NP_001129269.1

      Status: PROVISIONAL

      Source sequence(s)
      EU204919
      UniProtKB/TrEMBL
      B6CJX6, F6ZMA1, G7NLP6
      Conserved Domains (2) summary
      pfam00605
      Location:7 → 110
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:198 → 375
      IRF-3; Interferon-regulatory factor 3

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041772.1 Reference Mmul_10 Primary Assembly

      Range
      49629971..49637050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028838516.1 → XP_028694349.1  interferon regulatory factor 3 isoform X7

      Conserved Domains (2) summary
      pfam00605
      Location:7 → 109
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:195 → 248
      IRF-3; Interferon-regulatory factor 3

    2. XM_015124405.2 → XP_014979891.2  interferon regulatory factor 3 isoform X3

      UniProtKB/TrEMBL
      A0A5K1U635, G7NLP6
      Related
      ENSMMUP00000031525.3, ENSMMUT00000038424.3
      Conserved Domains (2) summary
      pfam00605
      Location:7 → 109
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:197 → 374
      IRF-3; Interferon-regulatory factor 3

    3. XM_028838509.1 → XP_028694342.1  interferon regulatory factor 3 isoform X1

      UniProtKB/TrEMBL
      F7GFL3, G7NLP6
      Conserved Domains (2) summary
      pfam00605
      Location:7 → 138
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:226 → 403
      IRF-3; Interferon-regulatory factor 3

    4. XM_028838512.1 → XP_028694345.1  interferon regulatory factor 3 isoform X3

      UniProtKB/TrEMBL
      A0A5K1U635, G7NLP6
      Conserved Domains (2) summary
      pfam00605
      Location:7 → 109
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:197 → 374
      IRF-3; Interferon-regulatory factor 3

    5. XM_015124407.2 → XP_014979893.2  interferon regulatory factor 3 isoform X1

      UniProtKB/TrEMBL
      F7GFL3, G7NLP6
      Conserved Domains (2) summary
      pfam00605
      Location:7 → 138
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:226 → 403
      IRF-3; Interferon-regulatory factor 3

    6. XM_028838511.1 → XP_028694344.1  interferon regulatory factor 3 isoform X3

      UniProtKB/TrEMBL
      A0A5K1U635, G7NLP6
      Conserved Domains (2) summary
      pfam00605
      Location:7 → 109
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:197 → 374
      IRF-3; Interferon-regulatory factor 3

    7. XM_015124404.2 → XP_014979890.2  interferon regulatory factor 3 isoform X2

      UniProtKB/TrEMBL
      G7NLP6
      Conserved Domains (3) summary
      pfam00605
      Location:7 → 109
      IRF; Interferon regulatory factor transcription factor
      pfam16665
      Location:121 → 205
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
      pfam10401
      Location:225 → 402
      IRF-3; Interferon-regulatory factor 3

    8. XM_015124402.2 → XP_014979888.2  interferon regulatory factor 3 isoform X2

      UniProtKB/TrEMBL
      G7NLP6
      Conserved Domains (3) summary
      pfam00605
      Location:7 → 109
      IRF; Interferon regulatory factor transcription factor
      pfam16665
      Location:121 → 205
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
      pfam10401
      Location:225 → 402
      IRF-3; Interferon-regulatory factor 3

    9. XM_028838515.1 → XP_028694348.1  interferon regulatory factor 3 isoform X7

      Conserved Domains (2) summary
      pfam00605
      Location:7 → 109
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:195 → 248
      IRF-3; Interferon-regulatory factor 3

    10. XM_028838510.1 → XP_028694343.1  interferon regulatory factor 3 isoform X2

      UniProtKB/TrEMBL
      G7NLP6
      Conserved Domains (3) summary
      pfam00605
      Location:7 → 109
      IRF; Interferon regulatory factor transcription factor
      pfam16665
      Location:121 → 205
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
      pfam10401
      Location:225 → 402
      IRF-3; Interferon-regulatory factor 3

    11. XM_028838514.1 → XP_028694347.1  interferon regulatory factor 3 isoform X6

      Conserved Domains (2) summary
      pfam00605
      Location:7 → 138
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:224 → 277
      IRF-3; Interferon-regulatory factor 3

    12. XM_028838507.1 → XP_028694340.1  interferon regulatory factor 3 isoform X1

      UniProtKB/TrEMBL
      F7GFL3, G7NLP6
      Conserved Domains (2) summary
      pfam00605
      Location:7 → 138
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:226 → 403
      IRF-3; Interferon-regulatory factor 3

    13. XM_028838508.1 → XP_028694341.1  interferon regulatory factor 3 isoform X1

      UniProtKB/TrEMBL
      F7GFL3, G7NLP6
      Related
      ENSMMUP00000029942.4, ENSMMUT00000032000.4
      Conserved Domains (2) summary
      pfam00605
      Location:7 → 138
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:226 → 403
      IRF-3; Interferon-regulatory factor 3

    14. XM_015124406.2 → XP_014979892.2  interferon regulatory factor 3 isoform X4

      UniProtKB/TrEMBL
      G7NLP6
      Conserved Domains (2) summary
      cl00096
      Location:21 → 74
      IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
      pfam10401
      Location:162 → 339
      IRF-3; Interferon-regulatory factor 3

    15. XM_028838513.1 → XP_028694346.1  interferon regulatory factor 3 isoform X5

      UniProtKB/TrEMBL
      G7NLP6
      Conserved Domains (2) summary
      cl00096
      Location:7 → 61
      IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
      pfam10401
      Location:149 → 326
      IRF-3; Interferon-regulatory factor 3
    Nucleotide Protein
    Heading Accession and Version

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