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    IL12B interleukin 12B [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 694747, updated on 17-Aug-2024

    Summary

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    Official Symbol
    IL12Bprovided by VGNC
    Official Full Name
    interleukin 12Bprovided by VGNC
    Primary source
    VGNC:VGNC:73706
    See related
    Ensembl:ENSMMUG00000021701
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See IL12B in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 6 NC_041759.1 (156734270..156749918, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 6 NC_027898.1 (157491148..157505543, complement)

    Chromosome 6 - NC_041759.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA68 Neighboring gene ubiquitin like domain containing CTD phosphatase 1 Neighboring gene U4atac minor spliceosomal RNA Neighboring gene uncharacterized LOC106999016 Neighboring gene uncharacterized LOC114678956

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Whole blood stimulation with Toll-like receptor (TLR)-7/8 and TLR-9 agonists induces interleukin-12p40 expression in plasmacytoid dendritic cells in rhesus macaques but not in humans. Koopman G, et al. Clin Exp Immunol, 2013 Oct. PMID 23750720, Free PMC Article
    2. Comparative sequence analysis of cytokine genes from human and nonhuman primates. Villinger F, et al. J Immunol, 1995 Oct 15. PMID 7561102
    3. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In rhesus macaques plasmacytoid dendritic cells in peripheral blood express IL-12p40 upon TLR-7/8 and TLR-9 stimulation, which could potentially affect their response to vaccination and viral infection.
      Title: Whole blood stimulation with Toll-like receptor (TLR)-7/8 and TLR-9 agonists induces interleukin-12p40 expression in plasmacytoid dendritic cells in rhesus macaques but not in humans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immunoglobulin mediated immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interleukin-12 subunit beta
    Names
    CLMF p40
    IL-12 subunit p40
    IL-12B
    cytotoxic lymphocyte maturation factor 40 kDa subunit
    interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044725.1 → NP_001038190.1  interleukin-12 subunit beta precursor

      See identical proteins and their annotated locations for NP_001038190.1

      Status: PROVISIONAL

      Source sequence(s)
      U19841
      UniProtKB/Swiss-Prot
      P48095
      UniProtKB/TrEMBL
      G7MVS6
      Conserved Domains (4) summary
      smart00408
      Location:42 → 90
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:235 → 325
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam10420
      Location:126 → 216
      IL12p40_C; Cytokine interleukin-12p40 C-terminus
      cd00096
      Location:43 → 51
      Ig; Ig strand B [structural motif]

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041759.1 Reference Mmul_10 Primary Assembly

      Range
      156734270..156749918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028849042.1 → XP_028704875.1  interleukin-12 subunit beta isoform X1

      UniProtKB/Swiss-Prot
      P48095
      UniProtKB/TrEMBL
      G7MVS6
      Related
      ENSMMUP00000028574.3, ENSMMUT00000030533.4
      Conserved Domains (4) summary
      smart00408
      Location:42 → 90
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:235 → 325
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam10420
      Location:126 → 216
      IL12p40_C; Cytokine interleukin-12p40 C-terminus
      cd00096
      Location:43 → 51
      Ig; Ig strand B [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48095.1 GenPept UniProtKB/Swiss-Prot:P48095

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials