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    ARHGEF35 Rho guanine nucleotide exchange factor 35 [ Homo sapiens (human) ]

    Gene ID: 445328, updated on 10-Dec-2024

    Summary

    Official Symbol
    ARHGEF35provided by HGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 35provided by HGNC
    Primary source
    HGNC:HGNC:33846
    See related
    Ensembl:ENSG00000213214 AllianceGenome:HGNC:33846
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARHGEF5L
    Expression
    Broad expression in thyroid (RPKM 25.8), colon (RPKM 15.5) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ARHGEF35 in Genome Data Viewer
    Location:
    7q35
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (144186083..144195879, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (145466560..145476351, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (143883176..143892972, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily AO member 1 pseudogene Neighboring gene ARHGEF35 antisense RNA 1 Neighboring gene CTAGE family member 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:143901531-143902093 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:143902094-143902655 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:143904530-143905158 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:143905159-143905786 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:143906415-143907042 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:143935567-143936068 Neighboring gene olfactory receptor family 2 subfamily A member 42 Neighboring gene OR2A1 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:143947746-143948246 Neighboring gene olfactory receptor family 2 subfamily A member 20 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    rho guanine nucleotide exchange factor 35
    Names
    Rho guanine nucleotide exchange factor (GEF) 35
    rho guanine nucleotide exchange factor 5-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003702.3NP_001003702.2  rho guanine nucleotide exchange factor 35

      See identical proteins and their annotated locations for NP_001003702.2

      Status: VALIDATED

      Source sequence(s)
      AC004889
      Consensus CDS
      CCDS34770.1
      UniProtKB/Swiss-Prot
      A5YM69, Q6ZUI2
      UniProtKB/TrEMBL
      A0A5F9ZGZ6
      Related
      ENSP00000367355.3, ENST00000378115.3
      Conserved Domains (1) summary
      pfam15441
      Location:1478
      ARHGEF5_35; Rho guanine nucleotide exchange factor 5/35
    2. NM_001368318.1NP_001355247.1  rho guanine nucleotide exchange factor 35

      Status: VALIDATED

      Source sequence(s)
      MH721903
      Consensus CDS
      CCDS34770.1
      UniProtKB/Swiss-Prot
      A5YM69, Q6ZUI2
      UniProtKB/TrEMBL
      A0A5F9ZGZ6
      Related
      ENSP00000510684.1, ENST00000688754.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      144186083..144195879 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654715.1 Reference GRCh38.p14 PATCHES

      Range
      140648..150440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332180.1XP_054188155.1  rho guanine nucleotide exchange factor 35 isoform X1

      UniProtKB/TrEMBL
      A0A5F9ZGZ6, A0A5F9ZH52

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      145466560..145476351 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358266.1XP_054214241.1  rho guanine nucleotide exchange factor 35 isoform X1

      UniProtKB/TrEMBL
      A0A5F9ZGZ6, A0A5F9ZH52