U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    CPA5 carboxypeptidase A5 [ Homo sapiens (human) ]

    Gene ID: 93979, updated on 10-Dec-2024

    Summary

    Official Symbol
    CPA5provided by HGNC
    Official Full Name
    carboxypeptidase A5provided by HGNC
    Primary source
    HGNC:HGNC:15722
    See related
    Ensembl:ENSG00000158525 MIM:609561; AllianceGenome:HGNC:15722
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002 [PubMed 11836249]).[supplied by OMIM, Mar 2008]
    Expression
    Restricted expression toward testis (RPKM 7.8) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CPA5 in Genome Data Viewer
    Location:
    7q32.2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (130344816..130374599)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (131658548..131682444)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (129984656..130008571)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene carboxypeptidase A4 Neighboring gene uncharacterized LOC105375503 Neighboring gene small nucleolar RNA U13 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129985848-129986818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26653 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129992089-129992735 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:130005327-130005828 Neighboring gene uncharacterized LOC105375504 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:130019942-130020463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26655 Neighboring gene carboxypeptidase A1 Neighboring gene centrosomal protein 41 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:130080543-130081297

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • FLJ35969

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in proteolysis  
    Component Evidence Code Pubs
    is_active_in extracellular space  

    General protein information

    Preferred Names
    carboxypeptidase A5
    Names
    testicular tissue protein Li 32
    NP_001120913.1
    NP_001120914.1
    NP_001305152.1
    NP_525124.3
    XP_005250767.1
    XP_005250769.1
    XP_011515000.1
    XP_011515005.1
    XP_024302767.1
    XP_024302768.1
    XP_024302769.1
    XP_047276991.1
    XP_047276992.1
    XP_047276993.1
    XP_047276994.1
    XP_047276995.1
    XP_054215322.1
    XP_054215323.1
    XP_054215324.1
    XP_054215325.1
    XP_054215326.1
    XP_054215327.1
    XP_054215328.1
    XP_054215329.1
    XP_054215330.1
    XP_054215331.1
    XP_054215332.1
    XP_054215333.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127441.2NP_001120913.1  carboxypeptidase A5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001120913.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 encode the same isoform (1).
      Source sequence(s)
      BC039362, BC053681, BK000187, KF495711
      Consensus CDS
      CCDS5819.1
      UniProtKB/Swiss-Prot
      G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
      UniProtKB/TrEMBL
      A4D1M2, B2RCS8
      Conserved Domains (2) summary
      cd03870
      Location:134434
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:48117
      Propep_M14; Carboxypeptidase activation peptide
    2. NM_001127442.2NP_001120914.1  carboxypeptidase A5 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001120914.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK131191, BC053681, BK000187
      Consensus CDS
      CCDS47713.1
      UniProtKB/Swiss-Prot
      Q8WXQ8
      Related
      ENSP00000393045.2, ENST00000431780.6
      Conserved Domains (2) summary
      pfam02244
      Location:44116
      Propep_M14; Carboxypeptidase activation peptide
      cl11393
      Location:134380
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
    3. NM_001318223.2NP_001305152.1  carboxypeptidase A5 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 encode the same isoform (1).
      Source sequence(s)
      AK315256, BC053681, BK000187
      Consensus CDS
      CCDS5819.1
      UniProtKB/Swiss-Prot
      G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
      UniProtKB/TrEMBL
      A4D1M2, B2RCS8
      Related
      ENSP00000418183.1, ENST00000461828.5
      Conserved Domains (2) summary
      cd03870
      Location:134434
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:48117
      Propep_M14; Carboxypeptidase activation peptide
    4. NM_080385.5NP_525124.3  carboxypeptidase A5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_525124.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform (1). Variants 1, 2, and 4 encode the same isoform.
      Source sequence(s)
      BC053681, BK000187
      Consensus CDS
      CCDS5819.1
      UniProtKB/Swiss-Prot
      G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
      UniProtKB/TrEMBL
      A4D1M2, B2RCS8
      Related
      ENSP00000417314.1, ENST00000474905.6
      Conserved Domains (2) summary
      cd03870
      Location:134434
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:48117
      Propep_M14; Carboxypeptidase activation peptide

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      130344816..130374599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421035.1XP_047276991.1  carboxypeptidase A5 isoform X1

      UniProtKB/Swiss-Prot
      G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
      UniProtKB/TrEMBL
      A4D1M2, B2RCS8
    2. XM_047421036.1XP_047276992.1  carboxypeptidase A5 isoform X1

      UniProtKB/Swiss-Prot
      G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
      UniProtKB/TrEMBL
      A4D1M2, B2RCS8
    3. XM_024447000.2XP_024302768.1  carboxypeptidase A5 isoform X1

      UniProtKB/Swiss-Prot
      G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
      UniProtKB/TrEMBL
      A4D1M2, B2RCS8
      Conserved Domains (2) summary
      cd03870
      Location:134434
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:48117
      Propep_M14; Carboxypeptidase activation peptide
    4. XM_047421037.1XP_047276993.1  carboxypeptidase A5 isoform X1

      UniProtKB/Swiss-Prot
      G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
      UniProtKB/TrEMBL
      A4D1M2, B2RCS8
    5. XM_024446999.2XP_024302767.1  carboxypeptidase A5 isoform X1

      UniProtKB/Swiss-Prot
      G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
      UniProtKB/TrEMBL
      A4D1M2, B2RCS8
      Related
      ENSP00000419025.2, ENST00000466363.6
      Conserved Domains (2) summary
      cd03870
      Location:134434
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:48117
      Propep_M14; Carboxypeptidase activation peptide
    6. XM_047421038.1XP_047276994.1  carboxypeptidase A5 isoform X2

    7. XM_005250710.2XP_005250767.1  carboxypeptidase A5 isoform X1

      See identical proteins and their annotated locations for XP_005250767.1

      UniProtKB/Swiss-Prot
      G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
      UniProtKB/TrEMBL
      A4D1M2, B2RCS8
      Conserved Domains (2) summary
      cd03870
      Location:134434
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:48117
      Propep_M14; Carboxypeptidase activation peptide
    8. XM_005250712.2XP_005250769.1  carboxypeptidase A5 isoform X1

      See identical proteins and their annotated locations for XP_005250769.1

      UniProtKB/Swiss-Prot
      G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
      UniProtKB/TrEMBL
      A4D1M2, B2RCS8
      Conserved Domains (2) summary
      cd03870
      Location:134434
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:48117
      Propep_M14; Carboxypeptidase activation peptide
    9. XM_024447001.2XP_024302769.1  carboxypeptidase A5 isoform X1

      UniProtKB/Swiss-Prot
      G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
      UniProtKB/TrEMBL
      A4D1M2, B2RCS8
      Conserved Domains (2) summary
      cd03870
      Location:134434
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:48117
      Propep_M14; Carboxypeptidase activation peptide
    10. XM_047421039.1XP_047276995.1  carboxypeptidase A5 isoform X3

    11. XM_011516703.2XP_011515005.1  carboxypeptidase A5 isoform X1

      See identical proteins and their annotated locations for XP_011515005.1

      UniProtKB/Swiss-Prot
      G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
      UniProtKB/TrEMBL
      A4D1M2, B2RCS8
      Related
      ENSP00000376907.3, ENST00000393213.7
      Conserved Domains (2) summary
      cd03870
      Location:134434
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:48117
      Propep_M14; Carboxypeptidase activation peptide
    12. XM_011516698.2XP_011515000.1  carboxypeptidase A5 isoform X1

      See identical proteins and their annotated locations for XP_011515000.1

      UniProtKB/Swiss-Prot
      G3V0G8, Q6ZNI6, Q86SE2, Q86XM3, Q8NA08, Q8WXQ8
      UniProtKB/TrEMBL
      A4D1M2, B2RCS8
      Related
      ENSP00000420237.1, ENST00000485477.5
      Conserved Domains (2) summary
      cd03870
      Location:134434
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:48117
      Propep_M14; Carboxypeptidase activation peptide

    RNA

    1. XR_007060171.1 RNA Sequence

    2. XR_007060172.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      131658548..131682444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359349.1XP_054215324.1  carboxypeptidase A5 isoform X1

      UniProtKB/TrEMBL
      B2RCS8
    2. XM_054359352.1XP_054215327.1  carboxypeptidase A5 isoform X1

      UniProtKB/TrEMBL
      B2RCS8
    3. XM_054359353.1XP_054215328.1  carboxypeptidase A5 isoform X1

      UniProtKB/TrEMBL
      B2RCS8
    4. XM_054359356.1XP_054215331.1  carboxypeptidase A5 isoform X1

      UniProtKB/TrEMBL
      B2RCS8
    5. XM_054359350.1XP_054215325.1  carboxypeptidase A5 isoform X1

      UniProtKB/TrEMBL
      B2RCS8
    6. XM_054359347.1XP_054215322.1  carboxypeptidase A5 isoform X1

      UniProtKB/TrEMBL
      B2RCS8
    7. XM_054359357.1XP_054215332.1  carboxypeptidase A5 isoform X2

    8. XM_054359351.1XP_054215326.1  carboxypeptidase A5 isoform X1

      UniProtKB/TrEMBL
      B2RCS8
    9. XM_054359354.1XP_054215329.1  carboxypeptidase A5 isoform X1

      UniProtKB/TrEMBL
      B2RCS8
    10. XM_054359358.1XP_054215333.1  carboxypeptidase A5 isoform X3

    11. XM_054359355.1XP_054215330.1  carboxypeptidase A5 isoform X1

      UniProtKB/TrEMBL
      B2RCS8
    12. XM_054359348.1XP_054215323.1  carboxypeptidase A5 isoform X1

      UniProtKB/TrEMBL
      B2RCS8
    Loading
    Loading
    External link. Please review our privacy policy.