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Asp
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asp
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ASP-YL9 peptide (89YLYNSLLQL97) induces release of IL-2, IFN-gamma, TNF-alpha, or MIP-1beta in antigen-specific CD8+ T-cells |
PubMed
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Envelope surface glycoprotein gp120
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env
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HIV-1 gp120 induces the release of cytokines MIP-1 alpha, MIP-1 beta, IL-6, IL10, and TNF-alpha in immature dentritic cells |
PubMed
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env
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The CCR5 chemokine receptor is required for the entry of macrophage-tropic HIV-1 into target cells; the HIV-1 gp120-CD4 complex binds CCR5, which inhibits the binding of the natural CCR5 ligands macrophage inflammatory protein (MIP)-1alpha and MIP-1beta |
PubMed
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env
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Neuroprotective chemokine CCL4 reduces HIV-1 gp120-mediated p38 MAPK activation |
PubMed
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env
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Exposure of macrophages to purified CCR5- or CXCR4-tropic HIV-1 envelope glycoprotein gp120 induces secretion of high levels of macrophage inflammatory protein 1alpha (MIP-1alpha), MIP-1beta, RANTES, and tumor necrosis factor alpha |
PubMed
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env
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NK cells exposed to CXCR4-tropic HIV-1 gp120 produce lower levels of CC chemokines RANTES, MIP-1alpha, and MIP-1beta compared with that produced from untreated NK cells |
PubMed
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env
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HIV-1 gp120 induced cell death is inhibited by a CCR5-mediated neuroprotective pathway that involves protein kinase Akt/PKB as an essential component and can be triggered by the CCR5 agonists MIP-1beta and RANTES |
PubMed
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env
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The chemokine receptor CCR5 is posttranslationally modified by sulfation of its N-terminal tyrosines; sulfated tyrosines contribute to the binding of CCR5 to MIP-1 alpha, MIP-1 beta, and HIV-1 gp120/CD4 complexes and to the ability of HIV-1 to enter cells |
PubMed
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env
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N-formyl-methionyl-leucylphenyl-alanine binding to formyl peptide receptor (FPR) results in significant attenuation of cell responses to CCR5 ligands and in inhibition of HIV-1 gp120-mediated fusion and infection of cells expressing CD4, CCR5, and FPR |
PubMed
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Envelope surface glycoprotein gp160, precursor
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env
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A significant level of MIP1B is upregulated when PBMCs are stimulated with HIV-1 gp140 |
PubMed
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Envelope transmembrane glycoprotein gp41
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env
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A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 inhibits activation of PBMCs and upregulates the expression of MIP-1beta in peptide-treated PBMCs |
PubMed
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env
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RANTES, MIP-1beta, and anti-CD4 antibodies inhibit CCR5-dependent cell-cell fusion mediated by HIV-1 gp120 and gp41 from macrophage-tropic isolates |
PubMed
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Nef
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nef
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HIV-1 Nef induces the production of two CC-chemokines, macrophage inflammatory proteins 1alpha and 1beta, in HIV-1-infected macrophages |
PubMed
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nef
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HIV-1 Nef-stimulated CD8+ T cells upregulate mRNAs expression for IFN-gamma, MIP-1alpha, MIP-1alphaP, MIP-1beta, TNFRSF9, XCL1, and GM-CSF compared to unstimulated cells |
PubMed
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nef
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The proportion of HIV-1 Nef-specific CD8+ T cells endowed with TNF-alpha+, IFN-gamma+, CD107A+, and MIP-1beta+ is significantly higher in patients with the lowest virus set point than those with the highest virus set point |
PubMed
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nef
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Secretion of MIP-1beta from Nef-specific CD8+ T cells is associated with nonprogressive HIV-1 infection |
PubMed
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nef
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A novel domain (K(92)EK) within Nef is required for Nef-dependent MIP-1beta production by infected macrophages |
PubMed
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nef
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HIV-1 Nef-pulsed iDCs downregulate MIP-1beta and RANTES expression in NK cells |
PubMed
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nef
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HIV-1 Nef expression by immature human and macaque dendritic cells (DCs) upregulates IL-6, IL-12, TNF-alpha, CXCL8, CCL3, and CCL4 release, but without upregulating co-stimulatory and other molecules characteristic of mature DCs |
PubMed
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Pr55(Gag)
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gag
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MVA-gag induces a significant release of cytokines such as IL-2R, IL-6, IL-8, TNF-alpha, IFN-gamma, MCP-1, MIP-1alpha, MIP-1beta, and RANTES by the infected monocyte-derived dendritic cells in comparison with uninfected cells |
PubMed
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gag
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The proportion of HIV-1 Gag-specific CD8+ T cells endowed with TNF-alpha+, IFN-gamma+, CD107A+, and MIP-1beta+ is significantly higher in patients with the lowest virus set point than those with the highest virus set point |
PubMed
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Tat
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tat
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HIV-1 Tat upregulates MIP-1beta expression in microglia, monocyte-derived dendritic cells, and activated APC, an effect that may play a role in HIV encephalitis and immunosuppression of uninfected T cells |
PubMed
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tat
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Wild-type Tat but not Cys-22 and oxidized Tat induces CD1A-expressing monocyte-derived dendritic cells (MDDC) maturation and increases the production of cytokines TNF-alpha, IL-12, MIP-1alpha, and MIP-1beta |
PubMed
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Vpr
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vpr
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HIV-1 Vpr downregulates the expression of beta chemokines in primary lymphocytes and macrophages, including MIP-1 alpha, MIP-1 beta, and RANTES |
PubMed
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capsid
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gag
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PLA-p24-loaded human monocyte-derived dendritic cells enhance the secretion of MIP-1beta, IL-6, IL-8, and TNF-alpha in comparison with PLA-loaded cells alone |
PubMed
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gag
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HIV-1 CA-stimulated CD8+ T cells upregulate mRNAs expression for IFN-gamma, MIP-1alpha, MIP-1alphaP, MIP-1beta, TNFRSF9, XCL1, and GM-CSF compared to unstimulated cells |
PubMed
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