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    MORC1 MORC family CW-type zinc finger 1 [ Homo sapiens (human) ]

    Gene ID: 27136, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MORC1provided by HGNC
    Official Full Name
    MORC family CW-type zinc finger 1provided by HGNC
    Primary source
    HGNC:HGNC:7198
    See related
    Ensembl:ENSG00000114487 MIM:603205; AllianceGenome:HGNC:7198
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT33; MORC; ZCW6
    Summary
    This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. [provided by RefSeq, Jan 2009]
    Expression
    Restricted expression toward testis (RPKM 9.4) See more
    Orthologs
    mouse all
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    Genomic context

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    See MORC1 in Genome Data Viewer
    Location:
    3q13.13
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (108958248..109118134, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (111678481..111838414, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (108677095..108836981, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene T cell receptor associated transmembrane adaptor 1 Neighboring gene guanylate cyclase activator 1C Neighboring gene small nucleolar RNA U3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20223 Neighboring gene MORC1 antisense RNA 1 Neighboring gene chromosome 3 open reading frame 85 Neighboring gene long intergenic non-protein coding RNA 488

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. MORC1 methylation and BDI are associated with microstructural features of the hippocampus and medial prefrontal cortex. Mundorf A, et al. J Affect Disord, 2021 Mar 1. PMID 33401128
    2. Investigation of MORC1 DNA methylation as biomarker of early life stress and depressive symptoms. Thomas M, et al. J Psychiatr Res, 2020 Jan. PMID 31683097, Free PMC Article
    3. Methylation of MORC1: A possible biomarker for depression? Mundorf A, et al. J Psychiatr Res, 2018 Aug. PMID 29890506
    4. MORC1 exhibits cross-species differential methylation in association with early life stress as well as genome-wide association with MDD. Nieratschker V, et al. Transl Psychiatry, 2014 Aug 26. PMID 25158004, Free PMC Article
    5. New gene family defined by MORC, a nuclear protein required for mouse spermatogenesis. Inoue N, et al. Hum Mol Genet, 1999 Jul. PMID 10369865

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MORC1 methylation and BDI are associated with microstructural features of the hippocampus and medial prefrontal cortex.
      Title: MORC1 methylation and BDI are associated with microstructural features of the hippocampus and medial prefrontal cortex.
    2. Investigation of MORC1 DNA methylation as biomarker of early life stress and depressive symptoms.
      Title: Investigation of MORC1 DNA methylation as biomarker of early life stress and depressive symptoms.
    3. The results of this study showed that DNA methylation in the MORC1 promoter region significantly correlates with the Beck Depression Inventory score in the examined non-clinical population.
      Title: Methylation of MORC1: A possible biomarker for depression?
    4. MORC1 is thus the first identified epigenetic marker of ELS to be present in blood cell progenitors at birth and in the brain in adulthood.
      Title: MORC1 exhibits cross-species differential methylation in association with early life stress as well as genome-wide association with MDD.
    5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
    EBI GWAS Catalog
    Genome-wide diet-gene interaction analyses for risk of colorectal cancer.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epigenetic programing of male pronucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrotransposition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transposable element silencing by heterochromatin formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in male germ cell nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MORC family CW-type zinc finger protein 1
    Names
    cancer/testis antigen 33
    microrchidia, mouse, homolog of

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014429.4 → NP_055244.3  MORC family CW-type zinc finger protein 1

      See identical proteins and their annotated locations for NP_055244.3

      Status: REVIEWED

      Source sequence(s)
      AC016948, AC112138, BC050307
      Consensus CDS
      CCDS2955.1
      UniProtKB/Swiss-Prot
      B4DYX1, E7ERX1, Q7L8E2, Q86VD1, Q9NSG7, Q9Y6D4
      Related
      ENSP00000232603.5, ENST00000232603.10
      Conserved Domains (3) summary
      pfam07496
      Location:482 → 527
      zf-CW; CW-type Zinc Finger
      cl00075
      Location:28 → 160
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
      cl23750
      Location:293 → 373
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      108958248..109118134 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005247362.3 → XP_005247419.1  MORC family CW-type zinc finger protein 1 isoform X2

      Conserved Domains (3) summary
      pfam07496
      Location:512 → 557
      zf-CW; CW-type Zinc Finger
      cl00075
      Location:28 → 160
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
      cl23750
      Location:293 → 373
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    2. XM_047447968.1 → XP_047303924.1  MORC family CW-type zinc finger protein 1 isoform X6

    3. XM_011512692.2 → XP_011510994.1  MORC family CW-type zinc finger protein 1 isoform X3

      Conserved Domains (3) summary
      pfam07496
      Location:484 → 529
      zf-CW; CW-type Zinc Finger
      cl00075
      Location:28 → 160
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
      cl23750
      Location:295 → 375
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    4. XM_011512693.2 → XP_011510995.1  MORC family CW-type zinc finger protein 1 isoform X5

      Conserved Domains (3) summary
      pfam07496
      Location:514 → 559
      zf-CW; CW-type Zinc Finger
      cl00075
      Location:28 → 160
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
      cl23750
      Location:295 → 375
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    5. XM_011512691.2 → XP_011510993.1  MORC family CW-type zinc finger protein 1 isoform X1

      Conserved Domains (3) summary
      pfam07496
      Location:514 → 559
      zf-CW; CW-type Zinc Finger
      cl00075
      Location:28 → 160
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
      cl23750
      Location:295 → 375
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    6. XM_011512694.1 → XP_011510996.1  MORC family CW-type zinc finger protein 1 isoform X7

      Conserved Domains (1) summary
      pfam07496
      Location:415 → 460
      zf-CW; CW-type Zinc Finger

    7. XM_011512696.2 → XP_011510998.1  MORC family CW-type zinc finger protein 1 isoform X8

      See identical proteins and their annotated locations for XP_011510998.1

      Conserved Domains (2) summary
      pfam07496
      Location:288 → 333
      zf-CW; CW-type Zinc Finger
      cl23750
      Location:69 → 149
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    8. XM_047447970.1 → XP_047303926.1  MORC family CW-type zinc finger protein 1 isoform X10

    9. XM_011512697.3 → XP_011510999.1  MORC family CW-type zinc finger protein 1 isoform X9

      Conserved Domains (1) summary
      pfam07496
      Location:263 → 308
      zf-CW; CW-type Zinc Finger

    10. XM_017006169.3 → XP_016861658.1  MORC family CW-type zinc finger protein 1 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      111678481..111838414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346172.1 → XP_054202147.1  MORC family CW-type zinc finger protein 1 isoform X2

    2. XM_054346175.1 → XP_054202150.1  MORC family CW-type zinc finger protein 1 isoform X6

    3. XM_054346173.1 → XP_054202148.1  MORC family CW-type zinc finger protein 1 isoform X3

    4. XM_054346174.1 → XP_054202149.1  MORC family CW-type zinc finger protein 1 isoform X5

    5. XM_054346171.1 → XP_054202146.1  MORC family CW-type zinc finger protein 1 isoform X1

    6. XM_054346176.1 → XP_054202151.1  MORC family CW-type zinc finger protein 1 isoform X7

    7. XM_054346178.1 → XP_054202153.1  MORC family CW-type zinc finger protein 1 isoform X8

    8. XM_054346177.1 → XP_054202152.1  MORC family CW-type zinc finger protein 1 isoform X8

    9. XM_054346180.1 → XP_054202155.1  MORC family CW-type zinc finger protein 1 isoform X10

    10. XM_054346179.1 → XP_054202154.1  MORC family CW-type zinc finger protein 1 isoform X9

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86VD1.2 GenPept UniProtKB/Swiss-Prot:Q86VD1

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