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    UCK2 uridine-cytidine kinase 2 [ Homo sapiens (human) ]

    Gene ID: 7371, updated on 10-Dec-2024

    Summary

    Official Symbol
    UCK2provided by HGNC
    Official Full Name
    uridine-cytidine kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:12562
    See related
    Ensembl:ENSG00000143179 MIM:609329; AllianceGenome:HGNC:12562
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UK; UMPK; TSA903
    Summary
    This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010]
    Expression
    Ubiquitous expression in colon (RPKM 6.8), small intestine (RPKM 6.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See UCK2 in Genome Data Viewer
    Location:
    1q24.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (165827614..165911618)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (165173785..165257744)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (165796851..165880855)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:165737716-165738392 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:165738393-165739068 Neighboring gene TMCO1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1502 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:165797205-165797758 Neighboring gene ribosomal protein L26 pseudogene 12 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:165812106-165812292 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:165819835-165820049 Neighboring gene Sharpr-MPRA regulatory region 1747 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:165830150-165830650 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:165830651-165831151 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2022 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:165867758-165868957 Neighboring gene Sharpr-MPRA regulatory region 10580 Neighboring gene Sharpr-MPRA regulatory region 2437 Neighboring gene microRNA 3658 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1505 Neighboring gene post-GPI attachment to proteins 2 pseudogene Neighboring gene MPRA-validated peak438 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1506 Neighboring gene RPS3A pseudogene 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (35 hits/1274 screens)

    EBI GWAS Catalog

    Description
    A genome-wide association study of testicular germ cell tumor.
    EBI GWAS Catalog
    Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.
    EBI GWAS Catalog
    Meta-analysis identifies four new loci associated with testicular germ cell tumor.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    nucleocapsid gag HIV-1 NC upregulates uridine-cytidine kinase 2 in HEK 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • DKFZp686M04245

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding  
    enables cytidine kinase activity PubMed 
    enables identical protein binding PubMed 
    enables uridine kinase activity PubMed 
    Process Evidence Code Pubs
    involved_in CMP biosynthetic process  
    involved_in CTP salvage PubMed 
    involved_in CTP salvage  
    involved_in UMP salvage PubMed 
    involved_in UMP salvage  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytosol  

    General protein information

    Preferred Names
    uridine-cytidine kinase 2
    Names
    cytidine monophosphokinase 2
    testis-specific protein TSA903
    uridine kinase
    uridine monophosphate kinase
    uridine monophosphokinase 2
    NP_001350497.1
    NP_036606.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363568.2NP_001350497.1  uridine-cytidine kinase 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL358115, AL451074
      Consensus CDS
      CCDS86027.1
      UniProtKB/TrEMBL
      A0A2R8Y653
      Related
      ENSP00000494961.1, ENST00000642653.1
      Conserved Domains (1) summary
      cd02023
      Location:13207
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    2. NM_012474.5NP_036606.2  uridine-cytidine kinase 2 isoform 1

      See identical proteins and their annotated locations for NP_036606.2

      Status: REVIEWED

      Source sequence(s)
      AL358115, BC002906, BM714864, DR762696
      Consensus CDS
      CCDS1252.1
      UniProtKB/Swiss-Prot
      Q5VV91, Q7KZV3, Q92528, Q96KG5, Q9BU42, Q9BZX2
      Related
      ENSP00000356853.4, ENST00000367879.9
      Conserved Domains (1) summary
      cd02023
      Location:22228
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      165827614..165911618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      165173785..165257744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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