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    GPR180 G protein-coupled receptor 180 [ Homo sapiens (human) ]

    Gene ID: 160897, updated on 10-Dec-2024

    Summary

    Official Symbol
    GPR180provided by HGNC
    Official Full Name
    G protein-coupled receptor 180provided by HGNC
    Primary source
    HGNC:HGNC:28899
    See related
    Ensembl:ENSG00000152749 MIM:607787; AllianceGenome:HGNC:28899
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ITR
    Summary
    This gene encodes a protein that is a member of the G protein-coupled receptor superfamily. This protein is produced predominantly in vascular smooth muscle cells and may play an important role in the regulation of vascular remodeling. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in fat (RPKM 4.6), thyroid (RPKM 2.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See GPR180 in Genome Data Viewer
    Location:
    13q32.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (94601857..94634661)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (93805369..93838171)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (95254111..95286915)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903191 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:95202297-95202796 Neighboring gene tRNA-Phe (anticodon GAA) 1-5 Neighboring gene TDP-glucose 4,6-dehydratase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7866 Neighboring gene Sharpr-MPRA regulatory region 4462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:95256499-95256998 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 5 Neighboring gene RNA, 5S ribosomal pseudogene 36 Neighboring gene NANOG hESC enhancer GRCh37_chr13:95313022-95313523 Neighboring gene VISTA enhancer hs796 Neighboring gene long intergenic non-protein coding RNA 391 Neighboring gene RNA, 7SL, cytoplasmic 585, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • DKFZp586C1322, DKFZp667K0825

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in membrane  

    General protein information

    Preferred Names
    integral membrane protein GPR180
    Names
    intimal thickness-related receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_180989.6NP_851320.1  integral membrane protein GPR180 precursor

      See identical proteins and their annotated locations for NP_851320.1

      Status: REVIEWED

      Source sequence(s)
      AL049452, AL359708, BC052243, CD110068, DB150630
      Consensus CDS
      CCDS9472.1
      UniProtKB/Swiss-Prot
      A8K1D5, Q86V85
      Related
      ENSP00000366157.4, ENST00000376958.5
      Conserved Domains (1) summary
      pfam10192
      Location:141405
      GpcrRhopsn4; Rhodopsin-like GPCR transmembrane domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      94601857..94634661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      93805369..93838171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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