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    ADAMTS9-AS2 ADAMTS9 antisense RNA 2 [ Homo sapiens (human) ]

    Gene ID: 100507098, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ADAMTS9-AS2provided by HGNC
    Official Full Name
    ADAMTS9 antisense RNA 2provided by HGNC
    Primary source
    HGNC:HGNC:42435
    See related
    Ensembl:ENSG00000241684 AllianceGenome:HGNC:42435
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Implicated in diabetic retinopathy. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in ovary (RPKM 6.7), endometrium (RPKM 4.3) and 18 other tissues See more
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    Genomic context

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    See ADAMTS9-AS2 in Genome Data Viewer
    Location:
    3p14.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (64684870..65011468)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (64728534..65055119)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (64670546..64997143)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 739, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:64526487-64527686 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 9 Neighboring gene ADAMTS9 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr3:64582623-64583210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:64627975-64628476 Neighboring gene NANOG hESC enhancer GRCh37_chr3:64663850-64664351 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:64670743-64671244 Neighboring gene uncharacterized LOC105377124 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:64930462-64931334 Neighboring gene MPRA-validated peak4685 silencer Neighboring gene uncharacterized LOC124909390 Neighboring gene MPRA-validated peak4686 silencer Neighboring gene uncharacterized LOC107986017

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A review on the role of ADAMTS9-AS2 in different disorders. Ghafouri-Fard S, et al. Pathol Res Pract, 2023 Mar. PMID 36746036
    2. LncRNA ADAMTS9-AS2 promotes tongue squamous cell carcinoma proliferation, migration and EMT via the miR-600/EZH2 axis. Li Y, et al. Biomed Pharmacother, 2019 Apr. PMID 30970517
    3. Upregulation of lncRNA ADAMTS9-AS2 Promotes Salivary Adenoid Cystic Carcinoma Metastasis via PI3K/Akt and MEK/Erk Signaling. Xie S, et al. Mol Ther, 2018 Dec 5. PMID 30217729, Free PMC Article
    4. [Overexpression of the long non-coding RNA ADAMTS9-AS2 suppresses colorectal cancer proliferation and metastasis]. Bu X, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2019 Jul 28. PMID 31413211
    5. Downregulation of long non-coding RNA ENSG00000241684 is associated with poor prognosis in advanced clear cell renal cell carcinoma. Su H, et al. Eur J Surg Oncol, 2018 Jun. PMID 29433989

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA ADAMTS9-AS2 regulates periodontal ligament cell migration under mechanical compression via ADAMTS9/fibronectin.
      Title: LncRNA ADAMTS9-AS2 regulates periodontal ligament cell migration under mechanical compression via ADAMTS9/fibronectin.
    2. A review on the role of ADAMTS9-AS2 in different disorders.
      Title: A review on the role of ADAMTS9-AS2 in different disorders.
    3. ADAMTS9-AS2 Promotes Angiogenesis of Brain Microvascular Endothelial Cells Through Regulating miR-185-5p/IGFBP-2 Axis in Ischemic Stroke.
      Title: ADAMTS9-AS2 Promotes Angiogenesis of Brain Microvascular Endothelial Cells Through Regulating miR-185-5p/IGFBP-2 Axis in Ischemic Stroke.
    4. The diagnostic significance of circulating lncRNA ADAMTS9-AS2 tumor biomarker in non-small cell lung cancer among the Egyptian population.
      Title: The diagnostic significance of circulating lncRNA ADAMTS9-AS2 tumor biomarker in non-small cell lung cancer among the Egyptian population.
    5. Long-Chain Noncoding RNA ADAMTS9-AS2 Regulates Proliferation, Migration, and Apoptosis in Bladder Cancer Cells Through Regulating miR-182-5p.
      Title: Long-Chain Noncoding RNA ADAMTS9-AS2 Regulates Proliferation, Migration, and Apoptosis in Bladder Cancer Cells Through Regulating miR-182-5p.
    6. ADAMTS9-AS2: A Functional Long Non-coding RNA in Tumorigenesis.
      Title: ADAMTS9-AS2: A Functional Long Non-coding RNA in Tumorigenesis.
    7. ADAMTS9-AS2 and CADM2 expression and association with the prognosis in esophageal squamous cell carcinoma.
      Title: ADAMTS9-AS2 and CADM2 expression and association with the prognosis in esophageal squamous cell carcinoma.
    8. Exosome-derived long non-coding RNA ADAMTS9-AS2 suppresses progression of oral submucous fibrosis via AKT signalling pathway.
      Title: Exosome-derived long non-coding RNA ADAMTS9-AS2 suppresses progression of oral submucous fibrosis via AKT signalling pathway.
    9. LncRNA ADAMTS9-AS2 suppresses the proliferation of gastric cancer cells and the tumorigenicity of cancer stem cells through regulating SPOP.
      Title: LncRNA ADAMTS9-AS2 suppresses the proliferation of gastric cancer cells and the tumorigenicity of cancer stem cells through regulating SPOP.
    10. LncRNA ADAMTS9-AS2 inhibits gastric cancer (GC) development and sensitizes chemoresistant GC cells to cisplatin by regulating miR-223-3p/NLRP3 axis.
      Title: LncRNA ADAMTS9-AS2 inhibits gastric cancer (GC) development and sensitizes chemoresistant GC cells to cisplatin by regulating miR-223-3p/NLRP3 axis.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
    EBI GWAS Catalog
    Genome-wide association analysis of age-at-onset in Alzheimer's disease.
    EBI GWAS Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
    EBI GWAS Catalog
    Seven new loci associated with age-related macular degeneration.
    EBI GWAS Catalog
    Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
    EBI GWAS Catalog
    White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • ADAMTS9 antisense RNA 2 (non-protein coding)

    Clone Names

    • DKFZp667E0523

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_038264.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121766, AC132007, AL832788, BC040632, DA927615
      Related
      ENST00000481312.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      64684870..65011468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      64728534..65055119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Research Materials