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    DLEU1 deleted in lymphocytic leukemia 1 [ Homo sapiens (human) ]

    Gene ID: 10301, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DLEU1provided by HGNC
    Official Full Name
    deleted in lymphocytic leukemia 1provided by HGNC
    Primary source
    HGNC:HGNC:13747
    See related
    Ensembl:ENSG00000176124 MIM:605765; AllianceGenome:HGNC:13747
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BCMS; DLB1; LEU1; LEU2; XTP6; BCMS1; DLEU2; LINC00021; NCRNA00021
    Expression
    Ubiquitous expression in testis (RPKM 1.6), colon (RPKM 1.5) and 25 other tissues See more
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    Genomic context

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    See DLEU1 in Genome Data Viewer
    Location:
    13q14.2-q14.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (50082169..50528643)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (49302750..49743563)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (50656305..51102779)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene deleted in lymphocytic leukemia 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:50656434-50657229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7759 Neighboring gene Sharpr-MPRA regulatory region 84 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5353 Neighboring gene microRNA 16-1 Neighboring gene microRNA 15a Neighboring gene NANOG hESC enhancer GRCh37_chr13:50695956-50696481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5354 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5355 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:50699798-50700508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5358 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5359 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:50715020-50715693 Neighboring gene ribosomal protein L18 pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7760 Neighboring gene uncharacterized LOC124900337 Neighboring gene ST13, Hsp70 interacting protein pseudogene 4 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:50818353-50819552 Neighboring gene NANOG hESC enhancer GRCh37_chr13:50823191-50823706 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:50850586-50851108 Neighboring gene Sharpr-MPRA regulatory region 6827 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:50952541-50953137 Neighboring gene ribosomal protein L34 pseudogene 26 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr13:51102968-51104167 Neighboring gene DLEU1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7761 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7762 Neighboring gene Sharpr-MPRA regulatory region 8262 Neighboring gene uncharacterized LOC107984568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7763 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7765 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7766 Neighboring gene deleted in lymphocytic leukemia 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7767 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7768 Neighboring gene DLEU7 antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. [Prognostic value and mechanism of long non-coding RNA DLEU1 in osteosarcoma]. Zhang JJ, et al. Zhongguo Gu Shang, 2023 Jun 25. PMID 37366099
    2. LncRNA DLEU1 facilitates the progression of oral squamous cell carcinoma by miR-126-5p/GAB1 axis. Sun KD, et al. Kaohsiung J Med Sci, 2022 Oct. PMID 36039933
    3. B-cell neoplasia associated gene with multiple splicing (BCMS): the candidate B-CLL gene on 13q14 comprises more than 560 kb covering all critical regions. Wolf S, et al. Hum Mol Genet, 2001 Jun 1. PMID 11406609
    4. The effects of DLEU1 gene expression in Burkitt lymphoma (BL): potential mechanism of chemoimmunotherapy resistance in BL. Lee S, et al. Oncotarget, 2017 Apr 25. PMID 28427156, Free PMC Article
    5. Survival‑related DLEU1 is associated with HPV infection status and serves as a biomarker in HPV‑infected cervical cancer. Dong A, et al. Mol Med Rep, 2022 Mar. PMID 35014679, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA DLEU1 promotes angiogenesis in diabetic foot ulcer wound healing by regulating miR-96-5p.
      Title: LncRNA DLEU1 promotes angiogenesis in diabetic foot ulcer wound healing by regulating miR-96-5p.
    2. [Prognostic value and mechanism of long non-coding RNA DLEU1 in osteosarcoma].
      Title: [Prognostic value and mechanism of long non-coding RNA DLEU1 in osteosarcoma].
    3. Overexpression of lncRNA DLEU1 in Gastric Cancer Tissues Compared to Adjacent Non-Tumor Tissues.
      Title: Overexpression of lncRNA DLEU1 in Gastric Cancer Tissues Compared to Adjacent Non-Tumor Tissues.
    4. LncRNA DLEU1 facilitates the progression of oral squamous cell carcinoma by miR-126-5p/GAB1 axis.
      Title: LncRNA DLEU1 facilitates the progression of oral squamous cell carcinoma by miR-126-5p/GAB1 axis.
    5. YY1-induced DLEU1/miR-149-5p Promotes Malignant Biological Behavior of Cholangiocarcinoma through Upregulating YAP1/TEAD2/SOX2.
      Title: YY1-induced DLEU1/miR-149-5p Promotes Malignant Biological Behavior of Cholangiocarcinoma through Upregulating YAP1/TEAD2/SOX2.
    6. Long non-coding RNA DLEU1 promotes malignancy of breast cancer by acting as an indispensable coactivator for HIF-1alpha-induced transcription of CKAP2.
      Title: Long non-coding RNA DLEU1 promotes malignancy of breast cancer by acting as an indispensable coactivator for HIF-1α-induced transcription of CKAP2.
    7. lncRNA DLEU1 Modulates Proliferation, Inflammation, and Extracellular Matrix Degradation of Chondrocytes through Regulating miR-671-5p.
      Title: lncRNA DLEU1 Modulates Proliferation, Inflammation, and Extracellular Matrix Degradation of Chondrocytes through Regulating miR-671-5p.
    8. DLEU1 promotes cell survival by preventing DYNLL1 degradation in esophageal squamous cell carcinoma.
      Title: DLEU1 promotes cell survival by preventing DYNLL1 degradation in esophageal squamous cell carcinoma.
    9. Survivalrelated DLEU1 is associated with HPV infection status and serves as a biomarker in HPVinfected cervical cancer.
      Title: Survival‑related DLEU1 is associated with HPV infection status and serves as a biomarker in HPV‑infected cervical cancer.
    10. LncRNA DLEU1 is overexpressed in premature ovarian failure and sponges miR-146b-5p to increase granulosa cell apoptosis.
      Title: LncRNA DLEU1 is overexpressed in premature ovarian failure and sponges miR-146b-5p to increase granulosa cell apoptosis.
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    EBI GWAS Catalog
    Genome-wide association study of anthropometric traits in Korcula Island, Croatia.
    EBI GWAS Catalog
    Genome-wide association study of lung function decline in adults with and without asthma.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.
    EBI GWAS Catalog
    Multiple common variants for celiac disease influencing immune gene expression.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • B-cell neoplasia-associated gene with multiple splicing
    • deleted in lymphocytic leukemia 1 (non-protein coding)
    • leukemia-associated protein 2
    • long intergenic non-protein coding RNA 21

    Clone Names

    • FLJ92453, MGC22430

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_002605.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AL137060
      Related
      ENST00000655550.2

    2. NR_109973.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AJ412024, AK095311, AL137060, DB444728
      Related
      ENST00000469754.4

    3. NR_109974.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon and contains multiple additional 3' terminal exons, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AJ412032, AJ412055, AL161424, DB444728
      Related
      ENST00000491615.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      50082169..50528643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      49302750..49743563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_005887.1: Suppressed sequence

      Description
      NM_005887.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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