U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    FLOT2 flotillin 2 [ Homo sapiens (human) ]

    Gene ID: 2319, updated on 10-Dec-2024

    Summary

    Official Symbol
    FLOT2provided by HGNC
    Official Full Name
    flotillin 2provided by HGNC
    Primary source
    HGNC:HGNC:3758
    See related
    Ensembl:ENSG00000132589 MIM:131560; AllianceGenome:HGNC:3758
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ESA; ECS1; ESA1; ECS-1; M17S1
    Summary
    Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 42.8), spleen (RPKM 42.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FLOT2 in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (28879339..28897733, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (29822120..29840508, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27206357..27224751, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903966 Neighboring gene CRISPRi-validated cis-regulatory element chr17.1493 Neighboring gene microRNA 4732 Neighboring gene microRNA 144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11955 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:27223968-27224468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8359 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:27228996-27229188 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8360 Neighboring gene dehydrogenase/reductase 13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27232864-27233364 Neighboring gene Sharpr-MPRA regulatory region 2481 Neighboring gene PHD finger protein 12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11957 Neighboring gene uncharacterized LOC101927018

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protease binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in anterograde dendritic transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epidermis development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of amyloid precursor protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of establishment of T cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to plasma membrane raft IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in regulation of heterotypic cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of myoblast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of myoblast differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IEA
    Inferred from Electronic Annotation
    more info
     
    NOT involved_in regulation of toll-like receptor 3 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in acrosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell contact zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    part_of flotillin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of flotillin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in focal adhesion HDA PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in uropod IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    flotillin-2
    Names
    Flotillin 2 (epidermal surface antigen 1)
    epidermal surface antigen
    membrane component chromosome 17 surface marker 1
    membrane component, chromosome 17, surface marker 1 (35kD protein identified by monoclonal antibody ECS-1)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330170.2NP_001317099.1  flotillin-2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC024267, BQ019299
      Consensus CDS
      CCDS82097.1
      UniProtKB/TrEMBL
      E7EMK3, J3QLD9
      Related
      ENSP00000463503.1, ENST00000585169.6
      Conserved Domains (2) summary
      COG2268
      Location:6417
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
      cd03399
      Location:34178
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    2. NM_004475.3NP_004466.2  flotillin-2 isoform 1

      See identical proteins and their annotated locations for NP_004466.2

      Status: REVIEWED

      Source sequence(s)
      AC024267, BC003683, BC017292, CA390100, M60922
      Consensus CDS
      CCDS11245.2
      UniProtKB/Swiss-Prot
      Q14254
      UniProtKB/TrEMBL
      E7EMK3
      Related
      ENSP00000378368.3, ENST00000394908.9
      Conserved Domains (2) summary
      COG2268
      Location:6417
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
      cd03399
      Location:34178
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      28879339..28897733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450667.2XP_024306435.1  flotillin-2 isoform X2

      Conserved Domains (2) summary
      COG2268
      Location:8340
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
      cd03399
      Location:1101
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    2. XM_017024394.2XP_016879883.1  flotillin-2 isoform X1

      UniProtKB/TrEMBL
      Q6FG43, Q9BTI6
      Conserved Domains (2) summary
      COG2268
      Location:1368
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
      cd03399
      Location:1129
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    3. XM_047435687.1XP_047291643.1  flotillin-2 isoform X1

      UniProtKB/TrEMBL
      Q6FG43, Q9BTI6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      29822120..29840508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315591.1XP_054171566.1  flotillin-2 isoform X1

      UniProtKB/TrEMBL
      Q6FG43, Q9BTI6
    2. XM_054315593.1XP_054171568.1  flotillin-2 isoform X2

    3. XM_054315592.1XP_054171567.1  flotillin-2 isoform X1

      UniProtKB/TrEMBL
      Q6FG43, Q9BTI6