Akr1a1 aldo-keto reductase family 1 member A1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Akr1a1provided by RGD
Official Full Name: aldo-keto reductase family 1 member A1provided by RGD
Primary source: RGD:68346
See related: EnsemblRapid:ENSRNOG00000016727 AllianceGenome:RGD:68346
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Akr1a4
Summary: Enables L-glucuronate reductase activity and glucuronolactone reductase activity. Involved in carboxylic acid metabolic process; cellular detoxification of aldehyde; and negative regulation of apoptotic process. Predicted to be located in apical plasma membrane. Predicted to be active in cytosol and synapse. Orthologous to human AKR1A1 (aldo-keto reductase family 1 member A1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 5068.0), Adrenal (RPKM 1749.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q35

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (135329605..135367037, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (130092945..130130277, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (135482068..135498693, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-glucuronate reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-glucuronate reductase activity	ISO Inferred from Sequence Orthology more info
enables S-nitrosoglutathione reductase (NADH) activity	ISO Inferred from Sequence Orthology more info
enables S-nitrosoglutathione reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables alcohol dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables aldose reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldose reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
NOT enables all-trans-retinol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
NOT enables all-trans-retinol dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables allyl-alcohol dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables glucuronolactone reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucuronolactone reductase activity	ISO Inferred from Sequence Orthology more info
enables glycerol dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables methylglyoxal reductase (NADPH) (acetol producing) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in D-glucuronate catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within D-glucuronate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in D-glucuronate catabolic process to D-xylulose 5-phosphate	ISO Inferred from Sequence Orthology more info
involved_in L-ascorbic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within L-ascorbic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in L-ascorbic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in aldehyde catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within aldehyde catabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular detoxification of aldehyde	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular detoxification of aldehyde	ISO Inferred from Sequence Orthology more info
involved_in daunorubicin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in doxorubicin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aldo-keto reductase family 1 member A1

Names: 3-DG-reducing enzyme; S-nitroso-CoA reductase; alcohol dehydrogenase; aldehyde reductase; glucuronate reductase; glucuronolactone reductase; scorR

NP_112262.1

EC 1.1.1.19

EC 1.1.1.2

EC 1.1.1.20

EC 1.1.1.372

EC 1.1.1.54

XP_038966744.1

EC 1.1.1.19

EC 1.1.1.2

EC 1.1.1.20

EC 1.1.1.372

EC 1.1.1.54

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031000.3 → NP_112262.1 aldo-keto reductase family 1 member A1

See identical proteins and their annotated locations for NP_112262.1

Status: PROVISIONAL

Source sequence(s)

D10854

UniProtKB/Swiss-Prot

P51635

UniProtKB/TrEMBL

A0A8I6AVC9, A6JZ88

Conserved Domains (1) summary

cd19106
Location:8 → 312

AKR_AKR1A1-4; AKR1A family of aldo-keto reductase (AKR)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

135329605..135367037 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110816.2 → XP_038966744.1 aldo-keto reductase family 1 member A1 isoform X1

UniProtKB/Swiss-Prot

P51635

UniProtKB/TrEMBL

A0A8I6AVC9, A6JZ88

Related

ENSRNOP00000023072.3, ENSRNOT00000023072.7

Conserved Domains (1) summary

cd19106
Location:8 → 312

AKR_AKR1A1-4; AKR1A family of aldo-keto reductase (AKR)