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    Dido1 death inducer-obliterator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362286, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dido1provided by RGD
    Official Full Name
    death inducer-obliterator 1provided by RGD
    Primary source
    RGD:1311173
    See related
    EnsemblRapid:ENSRNOG00000009936 AllianceGenome:RGD:1311173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Datf1
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within apoptotic signaling pathway. Predicted to be active in nucleus. Orthologous to human DIDO1 (death inducer-obliterator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 118.7), Spleen (RPKM 112.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dido1 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (188150100..188203445, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (167772535..167825894, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (176162886..176216868, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene transcription factor like 5 Neighboring gene ATP synthase membrane subunit f, pseudogene 2 Neighboring gene GID complex subunit 8 homolog Neighboring gene solute carrier family 17 member 9 Neighboring gene basic helix-loop-helix family, member e23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DIO-1 is a gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development. García-Domingo D, et al. Proc Natl Acad Sci U S A, 1999 Jul 6. PMID 10393935, Free PMC Article
    2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    death-inducer obliterator 1
    Names
    death associated transcription factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427308.1 → NP_001414237.1  death-inducer obliterator 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZXE0, A6KM85
      Related
      ENSRNOP00000082610.1, ENSRNOT00000113048.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      188150100..188203445 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235806.5 → XP_006235868.1  death-inducer obliterator 1 isoform X1

      See identical proteins and their annotated locations for XP_006235868.1

      UniProtKB/TrEMBL
      A0A8I5ZXE0, A6KM85
      Conserved Domains (7) summary
      smart00510
      Location:671 → 772
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      PHA03247
      Location:1564 → 2085
      PHA03247; large tegument protein UL36; Provisional
      COG5034
      Location:157 → 299
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      TIGR01622
      Location:2144 → 2182
      SF-CC1; splicing factor, CC1-like family
      cd15639
      Location:263 → 316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:1046 → 1194
      SPOC; SPOC domain
      pfam16495
      Location:1465 → 1502
      SWIRM-assoc_1; SWIRM-associated region 1

    2. XM_008762595.4 → XP_008760817.1  death-inducer obliterator 1 isoform X2

      See identical proteins and their annotated locations for XP_008760817.1

      UniProtKB/TrEMBL
      A6KM85, D3ZWL9
      Related
      ENSRNOP00000013189.6, ENSRNOT00000013189.10
      Conserved Domains (6) summary
      smart00510
      Location:632 → 733
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      cd15639
      Location:263 → 316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam01749
      Location:138 → 241
      IBB; Importin beta binding domain
      pfam02724
      Location:143 → 192
      CDC45; CDC45-like protein
      pfam07744
      Location:1015 → 1121
      SPOC; SPOC domain
      pfam16495
      Location:1425 → 1463
      SWIRM-assoc_1; SWIRM-associated region 1

    3. XM_063284235.1 → XP_063140305.1  death-inducer obliterator 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZXE0, A6KM85

    4. XM_039106760.2 → XP_038962688.1  death-inducer obliterator 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZXE0, A6KM85
      Conserved Domains (7) summary
      smart00510
      Location:671 → 772
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      PHA03247
      Location:1564 → 2085
      PHA03247; large tegument protein UL36; Provisional
      COG5034
      Location:157 → 299
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      TIGR01622
      Location:2144 → 2182
      SF-CC1; splicing factor, CC1-like family
      cd15639
      Location:263 → 316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:1046 → 1194
      SPOC; SPOC domain
      pfam16495
      Location:1465 → 1502
      SWIRM-assoc_1; SWIRM-associated region 1

    5. XM_006235807.5 → XP_006235869.1  death-inducer obliterator 1 isoform X1

      See identical proteins and their annotated locations for XP_006235869.1

      UniProtKB/TrEMBL
      A0A8I5ZXE0, A6KM85
      Conserved Domains (7) summary
      smart00510
      Location:671 → 772
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      PHA03247
      Location:1564 → 2085
      PHA03247; large tegument protein UL36; Provisional
      COG5034
      Location:157 → 299
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      TIGR01622
      Location:2144 → 2182
      SF-CC1; splicing factor, CC1-like family
      cd15639
      Location:263 → 316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:1046 → 1194
      SPOC; SPOC domain
      pfam16495
      Location:1465 → 1502
      SWIRM-assoc_1; SWIRM-associated region 1

    6. XM_063284236.1 → XP_063140306.1  death-inducer obliterator 1 isoform X4

    7. XM_008762596.4 → XP_008760818.1  death-inducer obliterator 1 isoform X3

      See identical proteins and their annotated locations for XP_008760818.1

      Conserved Domains (5) summary
      smart00510
      Location:671 → 772
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      cd15639
      Location:263 → 316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:1054 → 1160
      SPOC; SPOC domain
      pfam08619
      Location:147 → 262
      Nha1_C; Alkali metal cation/H+ antiporter Nha1 C terminus
      pfam15727
      Location:858 → 1040
      DUF4678; Domain of unknown function (DUF4678)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108612.1: Suppressed sequence

      Description
      NM_001108612.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: DIDO1 (GeneID:11083).
    Nucleotide Protein Strain
    Heading Accession and Version

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