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    Dntt deoxynucleotidyltransferase, terminal [ Mus musculus (house mouse) ]

    Gene ID: 21673, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnttprovided by MGI
    Official Full Name
    deoxynucleotidyltransferase, terminalprovided by MGI
    Primary source
    MGI:MGI:98659
    See related
    Ensembl:ENSMUSG00000025014 AllianceGenome:MGI:98659
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tdt
    Summary
    Enables DNA nucleotidylexotransferase activity. Acts upstream of or within DNA metabolic process. Predicted to be located in cytosol; euchromatin; and nuclear lumen. Predicted to be active in nucleus. Is expressed in bone marrow; ovary; submandibular gland; testis; and thymus. Orthologous to human DNTT (DNA nucleotidylexotransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward thymus adult (RPKM 111.5) See more
    Orthologs
    human all
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    Genomic context

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    See Dntt in Genome Data Viewer
    Location:
    19 C3; 19 34.32 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (41017701..41047964)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (41029275..41059525)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C330026H20 gene Neighboring gene STARR-positive B cell enhancer mm9_chr19:41090421-41090722 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:41103805-41103914 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:41105621-41105774 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:41113653-41113854 Neighboring gene ribosomal protein S10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_46143 Neighboring gene STARR-positive B cell enhancer mm9_chr19:41146037-41146338 Neighboring gene STARR-seq mESC enhancer starr_46144 Neighboring gene oligodendrocytic myelin paranodal and inner loop protein Neighboring gene tolloid-like 2 Neighboring gene STARR-seq mESC enhancer starr_46145 Neighboring gene transmembrane 9 superfamily member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The long isoform of terminal deoxynucleotidyl transferase enters the nucleus and, rather than catalyzing nontemplated nucleotide addition, modulates the catalytic activity of the short isoform. Benedict CL, et al. J Exp Med, 2001 Jan 1. PMID 11136823, Free PMC Article
    2. Valpha and Vbeta public repertoires are highly conserved in terminal deoxynucleotidyl transferase-deficient mice. Fazilleau N, et al. J Immunol, 2005 Jan 1. PMID 15611258
    3. Evidence that the long murine terminal deoxynucleotidyltransferase isoform plays no role in the control of V(D)J junctional diversity. Doyen N, et al. J Immunol, 2004 Jun 1. PMID 15153493
    4. Experience-dependent expression of terminal deoxynucleotidyl transferase in mouse brain. Peña De Ortiz S, et al. Neuroreport, 2003 Jun 11. PMID 12821797
    5. T cell repertoire diversity is required for relapses in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. Fazilleau N, et al. J Immunol, 2007 Apr 15. PMID 17404267

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dntt expression reveals developmental hierarchy and lineage specification of hematopoietic progenitors.
      Title: Dntt expression reveals developmental hierarchy and lineage specification of hematopoietic progenitors.
    2. Molecular dynamics simulations and structural analysis to decipher functional impact of a twenty residue insert in the ternary complex of mus musculus TdT isoform have been reported.
      Title: Molecular Dynamics Simulations and Structural Analysis to Decipher Functional Impact of a Twenty Residue Insert in the Ternary Complex of Mus musculus TdT Isoform.
    3. TdT is essential for the generation of the predominant higher-affinity DEX-responsive J558 clone
      Title: Terminal deoxynucleotidyl transferase is required for an optimal response to the polysaccharide α-1,3 dextran.
    4. The role of TdT ensures enhanced diversity and selection of private T cell receptor repertoires and promotes optimal CD8-positive T cell immunity, both within individuals and across the species as a whole.
      Title: Terminal deoxynucleotidyltransferase is required for the establishment of private virus-specific CD8+ TCR repertoires and facilitates optimal CTL responses.
    5. TdT plays a critical role in the magnitude and breadth of anti-viral T(CD8+) responses toward individual determinants
      Title: Terminal deoxynucleotidyl transferase establishes and broadens antiviral CD8+ T cell immunodominance hierarchies.
    6. tdt may be involved in learning and memory saving.
      Title: Experience-dependent expression of terminal deoxynucleotidyl transferase in mouse brain.
    7. onset of terminal deoxynucleotidyl transferase gene activation during T cell differentiation and thymic ontogeny
      Title: Substantial N diversity is generated in T cell receptor alpha genes at birth despite low levels of terminal deoxynucleotidyl transferase expression in mouse thymus.
    8. Structure-function analysis of proposed domains and motifs for known activity of TdT reveals nonessential role for tumor suppressor BRCA1 C-terminal (BRCT) domain and essential roles for second helix-hairpin-helix motif and entire C terminus of TdT.
      Title: Mutational analysis of terminal deoxynucleotidyltransferase-mediated N-nucleotide addition in V(D)J recombination.
    9. Production of M603-id antibody is TdT dependent, while generation of M167-id antibody is TdT independent.
      Title: The M603 idiotype is lost in the response to phosphocholine in terminal deoxynucleotidyl transferase-deficient mice.
    10. The role of this locus in autoantibody production in MRL/lpr mouse strain, and subsequent development of kidney disease.
      Title: Effect of genetic deficiency of terminal deoxynucleotidyl transferase on autoantibody production and renal disease in MRL/lpr mice.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA nucleotidylexotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA nucleotidylexotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA nucleotidylexotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via nonhomologous end joining IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to ATP IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to ATP ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in euchromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in euchromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA nucleotidylexotransferase
    Names
    terminal addition enzyme
    terminal deoxynucleotidyl transferase
    NP_001036693.1
    NP_033371.2
    XP_036017402.1
    XP_036017403.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001043228.1 → NP_001036693.1  DNA nucleotidylexotransferase isoform 2

      See identical proteins and their annotated locations for NP_001036693.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC126608, AF316015, BX639078
      Consensus CDS
      CCDS37984.1
      UniProtKB/Swiss-Prot
      P09838, Q99PD0, Q99PD1
      UniProtKB/TrEMBL
      Q3UZ80
      Related
      ENSMUSP00000107819.2, ENSMUST00000112200.3
      Conserved Domains (3) summary
      cd00141
      Location:166 → 508
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
      smart00292
      Location:32 → 111
      BRCT; breast cancer carboxy-terminal domain
      smart00483
      Location:163 → 509
      POLXc; DNA polymerase X family

    2. NM_009345.2 → NP_033371.2  DNA nucleotidylexotransferase isoform 1

      See identical proteins and their annotated locations for NP_033371.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC126608, AF316014, BX639078
      Consensus CDS
      CCDS29807.1
      UniProtKB/Swiss-Prot
      P09838
      Related
      ENSMUSP00000062078.5, ENSMUST00000051806.12
      Conserved Domains (3) summary
      cd00141
      Location:166 → 528
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
      smart00292
      Location:32 → 111
      BRCT; breast cancer carboxy-terminal domain
      smart00483
      Location:163 → 529
      POLXc; DNA polymerase X family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      41017701..41047964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161509.1 → XP_036017402.1  DNA nucleotidylexotransferase isoform X1

      Conserved Domains (2) summary
      smart00483
      Location:163 → 528
      POLXc; DNA polymerase X family
      cl00038
      Location:31 → 125
      BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains

    2. XM_036161510.1 → XP_036017403.1  DNA nucleotidylexotransferase isoform X2

      Conserved Domains (2) summary
      smart00483
      Location:163 → 508
      POLXc; DNA polymerase X family
      cl00038
      Location:31 → 125
      BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09838.4 GenPept UniProtKB/Swiss-Prot:P09838

    Gene LinkOut

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