U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Washc4 WASH complex subunit 4 [ Mus musculus (house mouse) ]

    Gene ID: 319277, updated on 9-Dec-2024

    Summary

    Official Symbol
    Washc4provided by MGI
    Official Full Name
    WASH complex subunit 4provided by MGI
    Primary source
    MGI:MGI:2441787
    See related
    Ensembl:ENSMUSG00000034560 AllianceGenome:MGI:2441787
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kiaa1033; mKIAA1033; A230046K03Rik
    Summary
    Involved in endosomal transport. Acts upstream of or within several processes, including endolysosomal toll-like receptor signaling pathway; neuromuscular process; and regulation of protein complex stability. Located in endosome. Part of WASH complex. Is expressed in early conceptus and oocyte. Used to study Wiskott-Aldrich syndrome. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 43. Orthologous to human WASHC4 (WASH complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta adult (RPKM 6.5), CNS E11.5 (RPKM 5.1) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Washc4 in Genome Data Viewer
    Location:
    10 C1; 10 41.29 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (83379073..83432350)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (83543620..83596473)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27394 Neighboring gene destrin pseudogene Neighboring gene aldehyde dehydrogenase 1 family, member L2 Neighboring gene adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 Neighboring gene STARR-seq mESC enhancer starr_27397 Neighboring gene STARR-seq mESC enhancer starr_27398 Neighboring gene STARR-seq mESC enhancer starr_27399 Neighboring gene STARR-seq mESC enhancer starr_27401 Neighboring gene RIKEN cDNA 1500009L16 gene Neighboring gene STARR-seq mESC enhancer starr_27402

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    part_of BLOC-1 complex  
    part_of BLOC-1 complex  
    part_of WASH complex  
    part_of WASH complex PubMed 
    part_of WASH complex  
    part_of WASH complex  
    part_of WASH complex PubMed 
    located_in early endosome membrane PubMed 
    is_active_in endosome  
    located_in endosome PubMed 
    located_in endosome  
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    WASH complex subunit 4
    Names
    WASH complex subunit 7
    WASH complex subunit SWIP

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033375.2NP_001028547.2  WASH complex subunit 4

      See identical proteins and their annotated locations for NP_001028547.2

      Status: VALIDATED

      Source sequence(s)
      AI605037, AK038582, AK161247, BQ561687
      Consensus CDS
      CCDS36015.1
      UniProtKB/Swiss-Prot
      Q3TTQ9, Q3UMB9, Q6ZPZ7, Q8CAK8, Q8CGK0
      Related
      ENSMUSP00000039322.6, ENSMUST00000038388.7
      Conserved Domains (3) summary
      pfam14744
      Location:612945
      WASH-7_mid; WASH complex subunit 7
      pfam14745
      Location:32600
      WASH-7_N; WASH complex subunit 7, N-terminal
      pfam14746
      Location:9661135
      WASH-7_C; WASH complex subunit 7, C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      83379073..83432350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155807.1XP_036011700.1  WASH complex subunit 4 isoform X1

      Conserved Domains (3) summary
      pfam14744
      Location:695994
      WASH-7_mid; WASH complex subunit 7
      pfam14745
      Location:122690
      WASH-7_N; WASH complex subunit 7, N-terminal
      pfam14746
      Location:10111180
      WASH-7_C; WASH complex subunit 7, C-terminal
    2. XM_017313963.3XP_017169452.1  WASH complex subunit 4 isoform X3

      Conserved Domains (3) summary
      pfam14744
      Location:424757
      WASH-7_mid; WASH complex subunit 7
      pfam14745
      Location:1412
      WASH-7_N; WASH complex subunit 7, N-terminal
      pfam14746
      Location:779947
      WASH-7_C; WASH complex subunit 7, C-terminal
    3. XM_030245113.2XP_030100973.1  WASH complex subunit 4 isoform X5

      Conserved Domains (3) summary
      pfam14744
      Location:200533
      WASH-7_mid; WASH complex subunit 7
      pfam14745
      Location:1188
      WASH-7_N; WASH complex subunit 7, N-terminal
      pfam14746
      Location:555723
      WASH-7_C; WASH complex subunit 7, C-terminal
    4. XM_006513737.4XP_006513800.2  WASH complex subunit 4 isoform X2

      Conserved Domains (3) summary
      pfam14744
      Location:568901
      WASH-7_mid; WASH complex subunit 7
      pfam14745
      Location:8556
      WASH-7_N; WASH complex subunit 7, N-terminal
      pfam14746
      Location:9231091
      WASH-7_C; WASH complex subunit 7, C-terminal
    5. XM_006513738.4XP_006513801.1  WASH complex subunit 4 isoform X4

      Conserved Domains (3) summary
      pfam14744
      Location:485818
      WASH-7_mid; WASH complex subunit 7
      pfam14745
      Location:1473
      WASH-7_N; WASH complex subunit 7, N-terminal
      pfam14746
      Location:8401008
      WASH-7_C; WASH complex subunit 7, C-terminal
    6. XM_006513739.4XP_006513802.1  WASH complex subunit 4 isoform X5

      Conserved Domains (3) summary
      pfam14744
      Location:200533
      WASH-7_mid; WASH complex subunit 7
      pfam14745
      Location:1188
      WASH-7_N; WASH complex subunit 7, N-terminal
      pfam14746
      Location:555723
      WASH-7_C; WASH complex subunit 7, C-terminal

    RNA

    1. XR_004936201.1 RNA Sequence

    External link. Please review our privacy policy.