Radx RPA1 related single stranded DNA binding protein, X-linked [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Radxprovided by MGI
Official Full Name: RPA1 related single stranded DNA binding protein, X-linkedprovided by MGI
Primary source: MGI:MGI:2147848
See related: Ensembl:ENSMUSG00000042498 AllianceGenome:MGI:2147848
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D330045A20Rik
Summary: Predicted to enable single-stranded DNA binding activity. Predicted to be involved in negative regulation of double-strand break repair via homologous recombination. Predicted to be located in nuclear speck. Predicted to be active in replication fork. Is expressed in extraembryonic ectoderm. Orthologous to human RADX (RPA1 related single stranded DNA binding protein, X-linked). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 1.2), genital fat pad adult (RPKM 0.5) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: X F1; X 61.35 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (138381116..138455333)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (139480367..139554584)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA repair	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in replication fork	IBA Inferred from Biological aspect of Ancestor more info
located_in replication fork	ISO Inferred from Sequence Orthology more info
located_in replication fork	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: RPA-related protein RADX

Names: likely orthologue of H. sapiens Chromosome X open reading frame 57 (CXorf57); uncharacterized protein CXorf57 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.