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    D7Ertd443e DNA segment, Chr 7, ERATO Doi 443, expressed [ Mus musculus (house mouse) ]

    Gene ID: 71007, updated on 9-Dec-2024

    Summary

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    Official Symbol
    D7Ertd443eprovided by MGI
    Official Full Name
    DNA segment, Chr 7, ERATO Doi 443, expressedprovided by MGI
    Primary source
    MGI:MGI:1196431
    See related
    Ensembl:ENSMUSG00000030994 AllianceGenome:MGI:1196431
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FATS; Gm497; 4933400E14Rik
    Summary
    Enables histone deacetylase binding activity and ubiquitin protein ligase activity. Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; protein stabilization; and response to ionizing radiation. Predicted to be located in actin cytoskeleton; cytoplasm; and plasma membrane. Predicted to be active in centriole; centrosome; and cytosol. Orthologous to human C10orf90 (chromosome 10 open reading frame 90). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 9.5) and cerebellum adult (RPKM 0.7) See more
    Orthologs
    human all
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    Genomic context

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    See D7Ertd443e in Genome Data Viewer
    Location:
    7 F3; 7 78.4 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (133867509..134121888, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (134265780..134520159, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20337 Neighboring gene ADAM metallopeptidase domain 12 Neighboring gene STARR-seq mESC enhancer starr_20338 Neighboring gene predicted gene, 51500 Neighboring gene predicted gene, 39103 Neighboring gene STARR-seq mESC enhancer starr_20339 Neighboring gene STARR-seq mESC enhancer starr_20340 Neighboring gene STARR-seq mESC enhancer starr_20341 Neighboring gene STARR-seq mESC enhancer starr_20343 Neighboring gene STARR-seq mESC enhancer starr_20344 Neighboring gene predicted gene, 35970 Neighboring gene STARR-seq mESC enhancer starr_20345 Neighboring gene STARR-seq mESC enhancer starr_20346 Neighboring gene methionine aminopeptidase 2 pseudogene Neighboring gene dedicator of cytokinesis 1 Neighboring gene STARR-seq mESC enhancer starr_20355 Neighboring gene STARR-seq mESC enhancer starr_20356 Neighboring gene inhibitory synaptic factor 2A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization. Zhang L, et al. Nat Commun, 2021 Jul 14. PMID 34262035, Free PMC Article
    2. FATS is a transcriptional target of p53 and associated with antitumor activity. Zhang X, et al. Mol Cancer, 2010 Sep 16. PMID 20843368, Free PMC Article
    3. An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis. Li Z, et al. Oncogene, 2010 May 6. PMID 20154723
    4. FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage. Yan S, et al. Oncogene, 2014 Nov 20. PMID 24240685
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone deacetylase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic G2 DNA damage checkpoint signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to UV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to ionizing radiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    (E2-independent) E3 ubiquitin-conjugating enzyme FATS
    Names
    E2/E3 hybrid ubiquitin-protein ligase FATS
    centrosomal protein C10orf90 homolog
    fragile-site associated tumor suppressor homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081331.2 → NP_001074800.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform 2

      See identical proteins and their annotated locations for NP_001074800.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC124369, AC126676
      Consensus CDS
      CCDS57590.1
      UniProtKB/Swiss-Prot
      D2J0Y4
      UniProtKB/TrEMBL
      Q3ULM5
      Related
      ENSMUSP00000091539.4, ENSMUST00000094002.10
      Conserved Domains (2) summary
      pfam15309
      Location:514 → 641
      ALMS_motif; ALMS motif
      pfam17730
      Location:5 → 509
      Centro_C10orf90; Centrosomal C10orf90

    2. NM_001199941.1 → NP_001186870.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      GQ499374
      Consensus CDS
      CCDS57591.1
      UniProtKB/TrEMBL
      G3UZF7, Q3ULM5
      Related
      ENSMUSP00000134479.2, ENSMUST00000172947.8
      Conserved Domains (1) summary
      pfam15309
      Location:561 → 689
      ALMS_motif; ALMS motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      133867509..134121888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241903.3 → XP_011240205.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X3

      UniProtKB/TrEMBL
      Q3ULM5
      Conserved Domains (2) summary
      pfam15309
      Location:530 → 657
      ALMS_motif; ALMS motif
      pfam17730
      Location:21 → 525
      Centro_C10orf90; Centrosomal C10orf90

    2. XM_011241905.4 → XP_011240207.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X4

      See identical proteins and their annotated locations for XP_011240207.1

      UniProtKB/Swiss-Prot
      D2J0Y4
      UniProtKB/TrEMBL
      Q3ULM5
      Conserved Domains (2) summary
      pfam15309
      Location:514 → 641
      ALMS_motif; ALMS motif
      pfam17730
      Location:5 → 509
      Centro_C10orf90; Centrosomal C10orf90

    3. XM_011241901.2 → XP_011240203.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X1

      See identical proteins and their annotated locations for XP_011240203.1

      UniProtKB/TrEMBL
      Q3ULM5
      Conserved Domains (2) summary
      pfam15309
      Location:591 → 718
      ALMS_motif; ALMS motif
      pfam17730
      Location:82 → 586
      Centro_C10orf90; Centrosomal C10orf90

    4. XM_011241906.3 → XP_011240208.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X5

      UniProtKB/TrEMBL
      Q3ULM5
      Conserved Domains (2) summary
      pfam15309
      Location:496 → 623
      ALMS_motif; ALMS motif
      pfam17730
      Location:82 → 491
      Centro_C10orf90; Centrosomal C10orf90

    5. XM_011241902.4 → XP_011240204.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X2

      UniProtKB/TrEMBL
      Q3ULM5
      Conserved Domains (2) summary
      pfam15309
      Location:545 → 672
      ALMS_motif; ALMS motif
      pfam17730
      Location:36 → 540
      Centro_C10orf90; Centrosomal C10orf90

    6. XM_011241904.4 → XP_011240206.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X4

      See identical proteins and their annotated locations for XP_011240206.1

      UniProtKB/Swiss-Prot
      D2J0Y4
      UniProtKB/TrEMBL
      Q3ULM5
      Conserved Domains (2) summary
      pfam15309
      Location:514 → 641
      ALMS_motif; ALMS motif
      pfam17730
      Location:5 → 509
      Centro_C10orf90; Centrosomal C10orf90

    7. XM_011241907.4 → XP_011240209.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X6

      See identical proteins and their annotated locations for XP_011240209.1

      UniProtKB/TrEMBL
      F7AZE7, Q9D4E0
      Related
      ENSMUSP00000101735.3, ENSMUST00000106129.9
      Conserved Domains (2) summary
      pfam15309
      Location:155 → 282
      ALMS_motif; ALMS motif
      pfam17730
      Location:3 → 150
      Centro_C10orf90; Centrosomal C10orf90
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D2J0Y4.1 GenPept UniProtKB/Swiss-Prot:D2J0Y4

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