mt-Cytb cytochrome b, mitochondrial [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: mt-Cytbprovided by MGI
Official Full Name: cytochrome b, mitochondrialprovided by MGI
Primary source: MGI:MGI:102501
See related: AllianceGenome:MGI:102501
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus (strain: C57BL/6J)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CYTB
Summary: Predicted to enable metal ion binding activity. Predicted to contribute to ubiquinol-cytochrome-c reductase activity. Predicted to be involved in several processes, including electron transport coupled proton transport; mitochondrial electron transport, ubiquinol to cytochrome c; and response to glucagon. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in ovarian carcinoma and urinary bladder cancer. Orthologous to human MT-CYB (mitochondrially encoded cytochrome b). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	MT (non-nuclear)	NC_005089.1 (14145..15288)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	MT (non-nuclear)	NC_005089.1 (14145..15288)

Chromosome MT - NC_005089.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitochondrial Genome-Encoded Long Noncoding RNA Cytochrome B and Mitochondrial Dysfunction in Diabetic Retinopathy.
Title: Mitochondrial Genome-Encoded Long Noncoding RNA Cytochrome B and Mitochondrial Dysfunction in Diabetic Retinopathy.
mt-Cytb mutations were studied in a mouse cultured cell model. Complex III assembly was impeded and caused a severe reduction in the amount of Complex I.
Title: Respiratory complex III is required to maintain complex I in mammalian mitochondria.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (2) 1 citation

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136450 (e-PCR)
- UniSTS:210436

RH136205 (e-PCR)
- UniSTS:210200

RH136495 (e-PCR)
- UniSTS:210478

PMC85197P1 (e-PCR)
- UniSTS:273467

RH136257 (e-PCR)
- UniSTS:210250

mt-Nd6 (e-PCR), detects polymorphism
- UniSTS:496723

RH136536 (e-PCR)
- UniSTS:210518

RH136271 (e-PCR)
- UniSTS:210264

RH136274 (e-PCR)
- UniSTS:210267

RH136546 (e-PCR)
- UniSTS:210528

RH136285 (e-PCR)
- UniSTS:210278

RH136633 (e-PCR)
- UniSTS:210613

RH136370 (e-PCR)
- UniSTS:210360

RH136382 (e-PCR)
- UniSTS:210372

Homology

Orthologs from OrthoDB

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
contributes_to ubiquinol-cytochrome-c reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquinol-cytochrome-c reductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in animal organ regeneration	IEA Inferred from Electronic Annotation more info
involved_in cellular respiration	NAS Non-traceable Author Statement more info	PubMed
involved_in electron transport coupled proton transport	IEA Inferred from Electronic Annotation more info
involved_in electron transport coupled proton transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	NAS Non-traceable Author Statement more info	PubMed
involved_in response to cadmium ion	IEA Inferred from Electronic Annotation more info
involved_in response to cadmium ion	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in response to cobalamin	IEA Inferred from Electronic Annotation more info
involved_in response to copper ion	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to glucagon	IEA Inferred from Electronic Annotation more info
involved_in response to glucagon	ISO Inferred from Sequence Orthology more info
involved_in response to hyperoxia	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to mercury ion	IEA Inferred from Electronic Annotation more info
involved_in response to mercury ion	ISO Inferred from Sequence Orthology more info
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex III	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex III	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex III	ISO Inferred from Sequence Orthology more info