Gemin4 gem nuclear organelle associated protein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gemin4provided by MGI
Official Full Name: gem nuclear organelle associated protein 4provided by MGI
Primary source: MGI:MGI:2449313
See related: Ensembl:ENSMUSG00000049396 AllianceGenome:MGI:2449313
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4932415L08Rik
Summary: Predicted to enable ribonucleoprotein complex binding activity. Predicted to be involved in spliceosomal snRNP assembly. Predicted to be located in Cajal body; cytosol; and nucleolus. Predicted to be part of SMN complex. Is expressed in brain and spinal cord. Human ortholog(s) of this gene implicated in alcohol dependence and neurodevelopmental disorder with microcephaly, cataracts, and renal abnormalities. Orthologous to human GEMIN4 (gem nuclear organelle associated protein 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 14.9), mammary gland adult (RPKM 7.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 45.92 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (76101397..76108398, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (76210571..76217572, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

General gene information

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Markers

AU015359 (e-PCR)
- UniSTS:180255

Dbil5 (e-PCR), detects polymorphism
- UniSTS:471173

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ribonucleoprotein complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in spliceosomal snRNP assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in spliceosomal snRNP assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Cajal body	ISO Inferred from Sequence Orthology more info
part_of SMN complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SMN complex	ISO Inferred from Sequence Orthology more info
part_of SMN-Sm protein complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gem-associated protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.