Tbx18 T-box transcription factor 18 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tbx18provided by RGD
Official Full Name: T-box transcription factor 18provided by RGD
Primary source: RGD:1309856
See related: EnsemblRapid:ENSRNOG00000010685 AllianceGenome:RGD:1309856
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including anterior/posterior pattern specification; negative regulation of canonical Wnt signaling pathway; and sinoatrial node cell differentiation. Predicted to act upstream of or within several processes, including cochlea morphogenesis; positive regulation of cell population proliferation; and sinoatrial node development. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of RNA polymerase II transcription repressor complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in CAKUT2. Orthologous to human TBX18 (T-box transcription factor 18). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 39.0), Muscle (RPKM 16.1) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (97531960..97559988, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (88652054..88680081, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (95359354..95387363, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-dependent suppression of biological pacemaker activity induced by TBX18.
Title: MicroRNA-dependent suppression of biological pacemaker activity induced by TBX18.
Tbx18 Orchestrates Cytostructural Transdifferentiation of Cardiomyocytes to Pacemaker Cells by Recruiting the Epithelial-Mesenchymal Transition Program.
Title: Tbx18 Orchestrates Cytostructural Transdifferentiation of Cardiomyocytes to Pacemaker Cells by Recruiting the Epithelial-Mesenchymal Transition Program.
our data demonstrate that TBX18-iPMs exhibit a low metabolic demand that matches their mitochondrial morphology and ability to withstand metabolic insult
Title: Induced cardiac pacemaker cells survive metabolic stress owing to their low metabolic demand.
indicated that transcription factor TBX18 could reprogram vascular smooth muscle cells into pacemaker-like cells in vitro
Title: Transcription Factor TBX18 Reprograms Vascular Smooth Muscle Cells of Ascending Aorta to Pacemaker-Like Cells.
The findings demonstrated that direct conversion of Bone mesenchymal stem cells to biological pacemaker cells via TBX18 is a feasible method in the field of cardiology.
Title: Transcription factor TBX18 promotes adult rat bone mesenchymal stem cell differentiation to biological pacemaker cells.

Submit: New GeneRIF Correction

General gene information

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Markers

RH139626 (e-PCR)
- UniSTS:221710

d8rat137 (e-PCR)
- UniSTS:122411

Tbx18 (e-PCR), detects polymorphism
- UniSTS:526946

AU048047 (e-PCR)
- UniSTS:109925

BF389194 (e-PCR)
- UniSTS:245403

RH133984 (e-PCR)
- UniSTS:217266

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anatomical structure formation involved in morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anterior/posterior axis specification	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell fate specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cochlea morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of mesenchymal cell proliferation involved in ureter development	ISO Inferred from Sequence Orthology more info
involved_in morphogenesis of embryonic epithelium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within morphogenesis of embryonic epithelium	ISO Inferred from Sequence Orthology more info
acts_upstream_of myoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in neural plate anterior/posterior regionalization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation involved in ureter development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of myoblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of stem cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of SA node cell action potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sinoatrial node cell development	ISO Inferred from Sequence Orthology more info
involved_in sinoatrial node cell fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sinoatrial node development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in somitogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within somitogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within stem cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of stem cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ureter development	ISO Inferred from Sequence Orthology more info
involved_in ureter development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription repressor complex	ISO Inferred from Sequence Orthology more info
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: T-box transcription factor TBX18

Names: T-box18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108173.1 → NP_001101643.1 T-box transcription factor TBX18

See identical proteins and their annotated locations for NP_001101643.1

Status: PROVISIONAL

Source sequence(s)

CH473954

UniProtKB/TrEMBL

A6I1X6, D4A1V6

Related

ENSRNOP00000014657.4, ENSRNOT00000014657.6

Conserved Domains (1) summary

cd00182
Location:145 → 340

TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...