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    Gstt2 glutathione S-transferase, theta 2 [ Mus musculus (house mouse) ]

    Gene ID: 14872, updated on 16-Dec-2024

    Summary

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    Official Symbol
    Gstt2provided by MGI
    Official Full Name
    glutathione S-transferase, theta 2provided by MGI
    Primary source
    MGI:MGI:106188
    See related
    Ensembl:ENSMUSG00000033318 AllianceGenome:MGI:106188
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Yrs; mGSTT2
    Summary
    Predicted to enable glutathione peroxidase activity and glutathione transferase activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human GSTT2 (glutathione S-transferase theta 2 (gene/pseudogene)) and GSTT2B (glutathione S-transferase theta 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in kidney adult (RPKM 150.6), liver adult (RPKM 57.5) and 19 other tissues See more
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    Genomic context

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    See Gstt2 in Genome Data Viewer
    Location:
    10 C1; 10 38.58 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75667676..75673253, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75831842..75837419, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase, theta 1 Neighboring gene glutathione S-transferase, theta 4 Neighboring gene STARR-positive B cell enhancer ABC_E9794 Neighboring gene STARR-positive B cell enhancer ABC_E5148 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:75300050-75300233 Neighboring gene predicted gene, 40697 Neighboring gene macrophage migration inhibitory factor (glycosylation-inhibiting factor)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Glutathione-S-Transferase Theta 2 (GSTT2) Modulates the Response to Bacillus Calmette-Guérin Immunotherapy in Bladder Cancer Patients. Rahmat JN, et al. Int J Mol Sci, 2024 Aug 16. PMID 39201633, Free PMC Article
    2. Glutathione S-transferases promote proinflammatory astrocyte-microglia communication during brain inflammation. Kano SI, et al. Sci Signal, 2019 Feb 19. PMID 30783009, Free PMC Article
    3. Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1. Whittington AT, et al. Genomics, 1996 Apr 1. PMID 8617493
    4. Mammalian class theta GST and differential susceptibility to carcinogens: a review. Landi S. Mutat Res, 2000 Oct. PMID 11018744
    5. Gene structure, expression and chromosomal localization of murine theta class glutathione transferase mGSTT1-1. Whittington A, et al. Biochem J, 1999 Jan 1. PMID 9854036, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Gene trapped (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutathione S-transferase theta-2
    Names
    GST class-theta-2
    NP_034491.2
    XP_006513303.1
    XP_006513304.1
    XP_011241675.1
    XP_030100749.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001428510.1 → NP_001415439.1  glutathione S-transferase theta-2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC142499

    2. NM_001428511.1 → NP_001415440.1  glutathione S-transferase theta-2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 4-7, encodes isoform c.
      Source sequence(s)
      AC142499

    3. NM_001428512.1 → NP_001415441.1  glutathione S-transferase theta-2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC142499

    4. NM_001428513.1 → NP_001415442.1  glutathione S-transferase theta-2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC142499

    5. NM_001428514.1 → NP_001415443.1  glutathione S-transferase theta-2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC142499

    6. NM_001428515.1 → NP_001415444.1  glutathione S-transferase theta-2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC142499

    7. NM_010361.3 → NP_034491.2  glutathione S-transferase theta-2 isoform b

      See identical proteins and their annotated locations for NP_034491.2

      Status: VALIDATED

      Source sequence(s)
      AC142499
      Consensus CDS
      CCDS48601.1
      UniProtKB/Swiss-Prot
      Q61133, Q61134, Q64472, Q91VB0
      Related
      ENSMUSP00000046324.7, ENSMUST00000038257.7
      Conserved Domains (2) summary
      cd03183
      Location:91 → 216
      GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
      cd03050
      Location:3 → 78
      GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      75667676..75673253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513241.1 → XP_006513304.1  glutathione S-transferase theta-2 isoform X3

      Conserved Domains (1) summary
      cd03183
      Location:52 → 177
      GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases

    2. XM_006513240.1 → XP_006513303.1  glutathione S-transferase theta-2 isoform X2

      See identical proteins and their annotated locations for XP_006513303.1

      UniProtKB/Swiss-Prot
      Q61133, Q61134, Q64472, Q91VB0
      Related
      ENSMUSP00000151239.2, ENSMUST00000220440.2
      Conserved Domains (2) summary
      cd03183
      Location:91 → 216
      GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
      cd03050
      Location:3 → 78
      GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...

    3. XM_011243373.1 → XP_011241675.1  glutathione S-transferase theta-2 isoform X1

      Conserved Domains (2) summary
      cd03183
      Location:98 → 223
      GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
      cd03050
      Location:3 → 85
      GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...

    4. XM_030244889.2 → XP_030100749.1  glutathione S-transferase theta-2 isoform X2

      UniProtKB/Swiss-Prot
      Q61133, Q61134, Q64472, Q91VB0
      Conserved Domains (2) summary
      cd03183
      Location:91 → 216
      GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
      cd03050
      Location:3 → 78
      GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61133.4 GenPept UniProtKB/Swiss-Prot:Q61133

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