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    Prl3d3 prolactin family 3, subfamily d, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 215029, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prl3d3provided by MGI
    Official Full Name
    prolactin family 3, subfamily d, member 3provided by MGI
    Primary source
    MGI:MGI:2660938
    See related
    Ensembl:ENSMUSG00000062201 AllianceGenome:MGI:2660938
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ghd6; Plig; PL-Ig
    Summary
    Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be active in extracellular space. Is expressed in ectoplacental cone; extraembryonic component; and placenta. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward placenta adult (RPKM 11.2) See more
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    Genomic context

    See Prl3d3 in Genome Data Viewer
    Location:
    13 A3.1; 13 12.3 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (27340777..27346576)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (27156794..27162593)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene prolactin family 3, subfamily d, member 1 Neighboring gene prolactin family 3, subfamily d, member 1 Neighboring gene prolactin family 3, subfamily c, member 1 Neighboring gene prolactin family 3, subfamily b, member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity  
    enables prolactin receptor binding  
    enables prolactin receptor binding  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway  
    involved_in female pregnancy  
    involved_in mammary gland development  
    involved_in positive regulation of lactation  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT  
    involved_in response to nutrient levels  
    Component Evidence Code Pubs
    is_active_in extracellular space  

    General protein information

    Preferred Names
    prolactin family 3, subfamily d, member 3
    Names
    PL-1 gamma
    growth hormone d6
    placental lactogen I gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361097.1 → NP_001348026.1  prolactin family 3, subfamily d, member 3 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      BC068253, CN691496, LM644173
      Consensus CDS
      CCDS88430.1
      UniProtKB/TrEMBL
      A0A0M6L0J6, Q8CGZ6
      Related
      ENSMUSP00000153035.2, ENSMUST00000223958.2
      Conserved Domains (1) summary
      cd10288
      Location:25 → 224
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones
    2. NM_172156.3 → NP_742168.1  prolactin family 3, subfamily d, member 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_742168.1

      Status: VALIDATED

      Source sequence(s)
      AL589679, BC068253, CN691496
      Consensus CDS
      CCDS26391.1
      UniProtKB/TrEMBL
      Q8CGZ6, Q8CGZ7
      Related
      ENSMUSP00000073286.4, ENSMUST00000073601.5
      Conserved Domains (1) summary
      cd10288
      Location:24 → 223
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      27340777..27346576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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